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A Comprehensive Understanding of Model Lipid Membranes: Concepts to Applications
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Type
Academic journal
Author
Sonam Baghel (Sushant University) Monika Khurana (Sushant University)
Journal
대한화학회 Journal of the Korean Chemical Society Vol.67 No.2 KCI Accredited Journals SCOPUS
Published
2023.4
Pages
89 - 98 (10page)

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A Comprehensive Understanding of Model Lipid Membranes: Concepts to Applications
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The cell membrane, also known as the biological membrane, surrounds every living cell. The main components of cell membranes are lipids and therefore called as lipid membranes. These membranes are mainly made up of a two-dimensional lipid bilayer along with integral and peripheral proteins. The complex nature of lipid membranes makes it difficult to study and hence artificial lipid membranes are prepared which mimic the original lipid membranes. These artificial lipid membranes are prepared from phospholipid vesicles (liposomes). The liposomes are formed when self-forming phospholipid bilayer comes in contact with water. Liposomes can be unilamellar or multilamellar vesicles which comprises of phospholipids that can be produced naturally or synthetically. The phospholipids are non-toxic, biodegradable and are readily produced on a large scale. These liposomes are mostly used in the drug delivery systems. This paper offers comprehensive literature with insights on developing basic understanding of lipid membranes from its structure, organization, and phase behavior to its potential use in biomedical applications. The progress in the field of artificial membrane models considering methods of preparation of liposomes for mimicking lipid membranes, interactions between the lipid membranes, and characterizing techniques such as UV-visible, FTIR, Calorimetry and X-ray diffraction are explained in a concise manner.
#Liposomes #Phospholipids #Bilayers #Fluidity #Lipid membrane

Contents

ABSTRACT
INTRODUCTION
RESULTS AND DISCUSSION
CONCLUSION
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