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논문 기본 정보

자료유형
학술저널
저자정보
Lim Sung Hee (Division of Hematology-Oncology Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) Kim Han Jo (Division of Hematology-Oncology Department of Medicine Soonchunhyang University Cheonan Hospital Cheonan Korea.) Kim Se Hyung (Division of Hematology-Oncology Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) Choi Seong Hyeok (Division of Hematology-Oncology Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) Kim Bora (Division of Hematology-Oncology Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) Kim Ji Youn (Division of Hematology-Oncology Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) Ji Young Sok (Division of Hematology-Oncology Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) Kim Tark (Division of Infectious Disease Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) Choo Eun Ju (Division of Infectious Disease Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) Jung Jung Chan (Department of Medical Biotechnology Soonchunhyang University Asan Korea.) Moon Ji Eun (Department of Biostatistics Clinical Trial Center Soonchunhyang University Bucheon Hospital Bucheon Korea.) Kim Chan Kyu (Division of Hematology-Oncology Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) Park Seong Kyu (Division of Hematology-Oncology Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.) Yun Jina (Division of Hematology-Oncology Department of Medicine Soonchunhyang University Bucheon Hospital Bucheon Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.13
발행연도
2023.4
수록면
1 - 12 (12page)
DOI
10.3346/jkms.2023.38.e103

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초록· 키워드

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Background: Although the primary vaccine coverage rate for coronavirus disease 2019 (COVID-19) in South Korea has exceeded 80%, the coronavirus continues to spread, with reports of a rapid decline in vaccine effectiveness. South Korea is administering booster shots despite concerns about the effectiveness of the existing vaccine. Methods: Neutralizing antibody inhibition scores were evaluated in two cohorts after the booster dose. For the first cohort, neutralizing activity against the wild-type, delta, and omicron variants after the booster dose was evaluated. For the second cohort, we assessed the difference in neutralizing activity between the omicron infected and uninfected groups after booster vaccination. We also compared the effectiveness and adverse events (AEs) between homologous and heterologous booster doses for BNT162b2 or ChAdOx1 vaccines. Results: A total of 105 healthcare workers (HCWs) that were additionally vaccinated with BNT162b2 at Soonchunhyang University Bucheon Hospital were enrolled in this study. Significantly higher surrogate virus neutralization test (sVNT) inhibition (%) was observed for the wild-type and delta variants compared to sVNT (%) for the omicron after the booster dose (97%, 98% vs. 75%; P < 0.001). No significant difference in the neutralizing antibody inhibition score was found between variants in the BNT/BNT/BNT group (n = 48) and the ChA/ChA/BNT group (n = 57). Total AEs were not significantly different between the ChA/ ChA/BNT group (85.96%) and the BNT/BNT group (95.83%; P = 0.11). In the second cohort with 58 HCWs, markedly higher sVNT inhibition to omicron was observed in the omicroninfected group (95.13%) compared to the uninfected group (mean of 48.44%; P < 0.001) after four months of the booster dose. In 41 HCWs (39.0%) infected with the omicron variant, no difference in immunogenicity, AEs, or effectiveness between homogeneous and heterogeneous boosters was observed. Conclusion: Booster vaccination with BNT162b2 was significantly less effective for the neutralizing antibody responses to omicron variant compared to the wild-type or delta variant in healthy population. Humoral immunogenicity was sustained significantly high after 4 months of booster vaccine in the infected population after booster vaccination. Further studies are needed to understand the characteristics of immunogenicity in these populations.
#Omicron Variant #Neutralizing Antibody #Breakthrough Infection #COVID-19

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