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논문 기본 정보

자료유형
학술저널
저자정보
Tasargol Omer (Department of Anesthesiology and Reanimation Doctor Burhan Nalbantoglu State Hospital) Darbaz Isfendiyar (Near East University Faculty of Veterinary Medicine) Ergene Osman (Near East University Faculty of Veterinary Medicine) Zabitler Feride (TRNC Ministry of Agriculture and Natural Resources) Deniz Aziz (TRNC Ministry of Agriculture and Natural Resources) Kose Selin Guven (Department of Anesthesiology and Pain Medicine Health Sciences University Derince Training and Research Hospital) Kose Halil Cihan (Department of Anesthesiology and Pain Medicine Health Sciences University Derince Training and Research Hospital) Tulgar Serkan (Department of Anesthesiology and Reanimation Samsun Training and Research Hospital)
저널정보
대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.76 No.2
발행연도
2023.4
수록면
152 - 159 (8page)
DOI
10.4097/kja.22486

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Background: Animal and other experimental studies have demonstrated increased block time and quality when α- and β-cyclodextrin drugs are combined with local anesthetics. However, to our knowledge, no study has utilized γ-cyclodextrins in such a combination. In the present study, we used an animal model to evaluate the effects of different doses of the combined administration of γ-cyclodextrin (sugammadex) and bupivacaine on the duration of sciatic nerve blocks in rats. Methods: Sciatic nerve blocks were performed with a 0.20 ml mixture in all groups. For the non-experimental groups, this mixture consisted of 0.2 ml saline (Sham group), 0.2 ml sugammadex (Group S), or 0.16 ml bupivacaine 0.5% and 0.04 ml saline (Group B). For the experimental groups, 0.16 ml bupivacaine 0.5% was administered along with 0.01 ml sugammadex and 0.03 ml saline (Group BS1), 0.02 ml sugammadex and 0.02 ml saline (Group BS2), or 0.04 ml sugammadex (Group BS4). Proprioception, nociception, and motor function were evaluated until the sciatic block was completely reversed.Results: Motor, proprioceptive, and nociceptive blockades occurred within 5 min in all experimental groups. In Group BS4, the duration of the motor, proprioceptive, and nociceptive blockades was significantly increased compared with the other experimental groups. However, in Groups BS1 and BS2, only the duration of the nociceptive blockade was significantly increased.Conclusions: The combined administration of sugammadex and bupivacaine for sciatic nerve blocks in rats led to a significant increase in the duration of motor, proprioceptive, and nociceptive blockades.

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