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Cameron Gofton (Storr Liver Centre Westmead Institute for Medical Research Westmead Hospital and University of Sydney Westmead NSW; Department of Gastroenterology and Hepatology Royal North Shore Hospital St Leonards) Yadhavan Upendran (Storr Liver Centre Westmead Institute for Medical Research Westmead Hospital and University of Sydney) Ming-Hua Zheng (MAFLD Research Center Department of Hepatology the First Affiliated Hospital of Wenzhou Medical University Wenzhou; Wenzhou Key Laboratory of Hepatology Wenzhou; Institute of Hepatology Wenzhou Medica) Jacob George (Storr Liver Centre Westmead Institute for Medical Research Westmead Hospital and University of Sydney)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제29권
발행연도
2023.2
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17 - 31 (15page)

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“Metabolic dysfunction-associated fatty liver disease (MAFLD)” is the term suggested in 2020 to refer to fatty liver disease related to systemic metabolic dysregulation. The name change from nonalcoholic fatty liver disease (NAFLD) to MAFLD comes with a simple set of criteria to enable easy diagnosis at the bedside for the general medical community, including primary care physicians. Since the introduction of the term, there have been key areas in which the superiority of MAFLD over the traditional NAFLD terminology has been demonstrated, including for the risk of liver and extrahepatic mortality, disease associations, and for identifying high-risk individuals. Additionally, MAFLD has been adopted by a number of leading pan-national and national societies due to its concise diagnostic criterion, removal of the requirement to exclude concomitant liver diseases, and reduction in the stigma associated with this condition. The current article explores the differences between MAFLD and NAFLD diagnosis, areas of benefit, some potential limitations, and how the MAFLD terminology has opened up new fields of research.

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