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논문 기본 정보

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학술저널
저자정보
Shanjie Wang (The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Heilongjiang Key Laboratory for Accurate Diagnosis and Treatment of Coronary Heart Disease Department of Cardiology Second Affil) Kegong Chen (Department of Thoracic Surgery First Affiliated Hospital of Anhui Medical University) Ye Wang (The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Heilongjiang Key Laboratory for Accurate Diagnosis and Treatment of Coronary Heart Disease Department of Cardiology Second Affil) Zeng Wang (The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Heilongjiang Key Laboratory for Accurate Diagnosis and Treatment of Coronary Heart Disease Department of Cardiology Second Affil) Zhaoying Li (The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Heilongjiang Key Laboratory for Accurate Diagnosis and Treatment of Coronary Heart Disease Department of Cardiology Second Affil) JunChen Guo (The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Heilongjiang Key Laboratory for Accurate Diagnosis and Treatment of Coronary Heart Disease Department of Cardiology Second Affil) Jianfeng Chen (Laboratory Animal Center Second Affiliated Hospital of Harbin Medical University) Wenhua Liu (Department of Intensive Care Medicine Second Affiliated Hospital of Harbin Medical University) Xiaohui Guo (Department of Pathology First Affiliated Hospital of Anhui Medical University) Guangcan Yan (Department of Epidemiology and Biostatistics School of Public Health Harbin Medical University) Chenchen Liang (The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Heilongjiang Key Laboratory for Accurate Diagnosis and Treatment of Coronary Heart Disease Department of Cardiology Second Affil) Huai Yu (The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Heilongjiang Key Laboratory for Accurate Diagnosis and Treatment of Coronary Heart Disease Department of Cardiology Second Affil) Shaohong Fang (The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Heilongjiang Key Laboratory for Accurate Diagnosis and Treatment of Coronary Heart Disease Department of Cardiology Second Affil) Bo Yu (The Key Laboratory of Myocardial Ischemia Chinese Ministry of Education Heilongjiang Key Laboratory for Accurate Diagnosis and Treatment of Coronary Heart Disease Department of Cardiology Second Affil)
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한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
1,146 - 1,162 (17page)
DOI
https://doi.org/10.1186/s40824-023-00377-8

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Background Large-dose melatonin treatment in animal experiments was hardly translated into humans, which may explain the dilemma that the protective effects against myocardial injury in animal have been challenged by clinical trials. Ultrasound-targeted microbubble destruction (UTMD) has been considered a promising drug and gene delivery system to the target tissue. We aim to investigate whether cardiac gene delivery of melatonin receptor mediated by UTMD technology optimizes the efficacy of clinically equivalent dose of melatonin in sepsis-induced cardiomyopathy. Methods Melatonin and cardiac melatonin receptors in patients and rat models with lipopolysaccharide (LPS)- or cecal ligation and puncture (CLP)-induced sepsis were assessed. Rats received UTMD-mediated cardiac delivery of RORα/cationic microbubbles (CMBs) at 1, 3 and 5 days before CLP surgery. Echocardiography, histopathology and oxylipin metabolomics were assessed at 16–20 h after inducing fatal sepsis. Results We observed that patients with sepsis have lower serum melatonin than healthy controls, which was observed in the blood and hearts of Sprague–Dawley rat models with LPS- or CLP-induced sepsis. Notably, a mild dose (2.5 mg/kg) of intravenous melatonin did not substantially improve septic cardiomyopathy. We found decreased nuclear receptors RORα, not melatonin receptors MT1/2, under lethal sepsis that may weaken the potential benefits of a mild dose of melatonin treatment. In vivo, repeated UTMD-mediated cardiac delivery of RORα/CMBs exhibited favorable biosafety, efficiency and specificity, significantly strengthening the effects of a safe dose of melatonin on heart dysfunction and myocardial injury in septic rats. The cardiac delivery of RORα by UTMD technology and melatonin treatment improved mitochondrial dysfunction and oxylipin profiles, although there was no significant influence on systemic inflammation. Conclusions These findings provide new insights to explain the suboptimal effect of melatonin use in clinic and potential solutions to overcome the challenges. UTMD technology may be a promisingly interdisciplinary pattern against sepsis-induced cardiomyopathy.
#Melatonin #RORα #Ultrasound-targeted microbubble destruction #UTMD #Sepsis-induced cardiomyopathy #Oxidative stress #Mitochondria

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