메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Fupeng Li (Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Key Laboratory of Orthopaedic Implants Shanghai Jiao Tong University School of Medicine) Kai Huang (Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Key Laboratory of Orthopaedic Implants Shanghai Jiao Tong University School of Medicine) Jinbing Wang (Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s Hospital College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases) Kai Yuan (Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Key Laboratory of Orthopaedic Implants Shanghai Jiao Tong University School of Medicine) Yiqi Yang (Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Key Laboratory of Orthopaedic Implants Shanghai Jiao Tong University School of Medicine) Yihao Liu (Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Key Laboratory of Orthopaedic Implants Shanghai Jiao Tong University School of Medicine) Xianhao Zhou (Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Key Laboratory of Orthopaedic Implants Shanghai Jiao Tong University School of Medicine) Keyu Kong (Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Key Laboratory of Orthopaedic Implants Shanghai Jiao Tong University School of Medicine) Tao Yang (Department of Materials Science and Engineering Hong Kong Institute for Advanced Study College of Science and Engineering City University of Hong Kong) Jian He (M-Duke Medical Technology (Shanghai) Co. Ltd) Chunjie Liu (M-Duke Medical Technology (Shanghai) Co. Ltd) Haiyong Ao (East China Jiaotong University) Fengxiang Liu (Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Key Laboratory of Orthopaedic Implants Shanghai Jiao Tong University School of Medicine) Qian Liu (Department of laboratory medicine Ren Ji Hospital Shanghai Jiao tong university school of medicine) Tingting Tang (Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Key Laboratory of Orthopaedic Implants Shanghai Jiao Tong University School of Medicine) Shengbing Yang (Department of Orthopaedic Surgery Shanghai Ninth People’s Hospital Shanghai Key Laboratory of Orthopaedic Implants Shanghai Jiao Tong University School of Medicine)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
788 - 805 (18page)
DOI
https://doi.org/10.1186/s40824-023-00362-1

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background : Although biomedical implants have been widely used in orthopedic treatments, two major clinical challenges remain to be solved, one is the bacterial infection resulting in biofilm formation, and the other is aseptic loosening during implantation due to over-activated osteoclastogenesis. These factors can cause many clinical issues and even lead to implant failure. Thus, it is necessary to endow implants with antibiofilm and aseptic loosening-prevention properties, to facilitate the integration between implants and bone tissues for successful implantation. To achieve this goal, this study aimed to develop a biocompatible titanium alloy with antibiofilm and anti-aseptic loosening dual function by utilizing gallium (Ga) as a component. Methods : A series of Ti-Ga alloys were prepared. We examined the Ga content, Ga distribution, hardness, tensile strength, biocompatibility, and anti-biofilm performance in vitro and in vivo. We also explored how Ga3+ ions inhibited the biofilm formation of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) and osteoclast differentiation. Results : The alloy exhibited outstanding antibiofilm properties against both S. aureus and E. coli in vitro and decent antibiofilm performance against S. aureus in vivo. The proteomics results demonstrated that Ga3+ ions could disturb the bacterial Fe metabolism of both S. aureus and E. coli, inhibiting bacterial biofilm formation. In addition, Ti-Ga alloys could inhibit receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclast differentiation and function by targeting iron metabolism, then suppressing the activation of the NF-κB signaling pathway, thus, showing their potential to prevent aseptic loosening. Conclusion : This study provides an advanced Ti-Ga alloy that can be used as a promising orthopedic implant raw material for various clinical scenarios. This work also revealed that iron metabolism is the common target of Ga3+ ions to inhibit biofilm formation and osteoclast differentiation.
#Ti-Ga alloy #Anti-biofilm #Implant-associated infections #Bacterial adhesion

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청
참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0