지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 88 - 98 (11page)
- DOI
- 10.5213/inj.2346068.034
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초록· 키워드
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Purpose: The main treatment options of neurogenic bladder remains catheterization and long-term oral medications. Meta bolic interventions have shown good therapeutic results in many diseases. To date, no studies have characterized the metabo lites of the detrusor muscle during neurogenic bladder. Using metabolomics, new muscle metabolomic signatures were identi fied to reveal the temporal metabolic profile of muscle during disease progression.
Methods: We used 42 Sprague-Dawley rats (200±20 g, males) for T10 segmental spinal cord injury modeling and collected detrusor tissue and performed nontargeted metabolomics after sham surgery, 30-minute, 6-hour, 12-hour, 24-hour, 5-day, and 2-week postmodelling, to identify the dysregulated metabolic pathways and key metabolites.
Results: By comparing mzCloud, mzVault, MassList, we identified a total of 1,271 metabolites and enriched a total of 12 me tabolism-related pathways with significant differences (P<0.05) based on Kyoto Encyclopedia of Genes and Genomes analysis.
Metabolites in several differential metabolic pathways such as ascorbate and aldarate metabolism, Steroid hormone biosynthe sis, and carbon metabolism are altered in a regular manner before and after ridge shock.
Conclusions: Our study is the first time-based metabolomic study of rat forced urinary muscle after traumatic spinal cord in jury, and we identified multiple differential metabolic pathways during injury that may improve long-term management strat egies for neurogenic bladder and reduce costs in long-term treatment.
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