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논문 기본 정보

자료유형
학술저널
저자정보
Kim Si-Young (Seoul National University) Surh Young-Joon (Cancer Research Institute Seoul National University Seoul KoreaResearch Institute of Pharmaceutical Sciences College of Pharmacy Seoul National University Seoul Korea) Lee Young-Soo (Sejong University)
저널정보
대한암예방학회 대한암예방학회지 대한암예방학회지 제28권 제1호
발행연도
2023.3
수록면
3 - 11 (9page)
DOI
10.15430/JCP.2023.28.1.3

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초록· 키워드

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In the present study, we investigated the effects of exhaustive exercise and recovery on inflammatory, pro-apoptotic, and anti-ox idative responses in human peripheral blood mononuclear cells (PBMCs). Sixteen volunteers participated in a guided physical activity program in which they were subjected to progressive exercise on the treadmill until they were exhausted followed by an 1-hour recovery period. Isolated human PBMCs were collected before exercise, immediately after exercise, and after 1-hour recov ery. Exhaustive exercise induced expression of heme oxygenase-1 and glutamate cysteine ligase catalytic subunit and activation of NF-κB and NF-E2 related factor 2 (Nrf2). Apoptosis, as measured by activity and cleavage of caspase-3 and its substrate PARP also significantly increased. However, induction of redox signaling and the pro-apoptotic response fully returned to the baseline level during the 1-hour recovery period. On the other hand, COX-2 expression was continuously elevated after exercise cessation throughout the 1-hour recovery period. Taking all these findings into account, we conclude that exhaustive exercise transiently in duces Nrf2-mediated antioxidant gene expression and eliminates damaged cells through apoptosis as part of an adaptive cytopro tective response against oxidative and inflammatory stress.

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