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논문 기본 정보

자료유형
학술저널
저자정보
Vineeth Mohan (Multimodal Brain Image Analysis Laboratory) Pravesh Parekh (Multimodal Brain Image Analysis Laboratory) Ammu Lukose (Multimodal Brain Image Analysis Laboratory) Sydney Moirangthem (National Institute of Mental Health and Neurosciences) Jitender Saini (National Institute of Mental Health and Neurosciences) David J. Schretlen (The Johns Hopkins University) John P. John (Multimodal Brain Image Analysis Laboratory (MBIAL))
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제21권 제2호
발행연도
2023.5
수록면
340 - 358 (19page)
DOI
10.9758/cpn.2023.21.2.340

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초록· 키워드

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Objective: Schizophrenia is associated with impairment in multiple cognitive domains. There is a paucity of research on the effect of prolonged illness duration (≥ 15 years) on cognitive performance along multiple domains. In this pilot study, we used the Global Neuropsychological Assessment (GNA), a brief cognitive battery, to explore the patterns of cognitive impairment in recent-onset (≤ 2 years) compared to chronic schizophrenia (≥ 15 years), and correlate cognitive performance with brain morphometry in patients and healthy adults. Methods: We assessed cognitive performance in patients with recent-onset (n = 17, illness duration ≤ 2 years) and chronic schizophrenia (n = 14, duration ≥ 15 years), and healthy adults (n = 16) using the GNA and examined correlations between cognitive scores and gray matter volumes computed from T1-weighted magnetic resonance imaging images. Results: We observed cognitive deficits affecting multiple domains in the schizophrenia samples. Selectively greater impairment of perceptual comparison speed was found in adults with chronic schizophrenia (p = 0.009, η2 partial = 0.25). In the full sample (n = 47), perceptual comparison speed correlated significantly with gray matter volumes in the anterior and medial temporal lobes (TFCE, FWE p < 0.01). Conclusion: Along with generalized deficit across multiple cognitive domains, selectively greater impairment of percep tual comparison speed appears to characterize chronic schizophrenia. This pattern might indicate an accelerated or premature cognitive aging. Anterior-medial temporal gray matter volumes especially of the left hemisphere might under lie the impairment noted in this domain in schizophrenia.

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