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논문 기본 정보

자료유형
학술저널
저자정보
Joyeta Mahmud (University of Science and Technology) Hien Thi My Ong (University of Science and Technology) Eda Ates (Hien Thi My Ong) Hong Seog Seo (Korea University Medicine) 강민정 (한국과학기술연구원)
저널정보
대한생화학·분자생물학회 BMB Reports BMB Reports 제56권 제6호
발행연도
2023.6
수록면
341 - 346 (6page)

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Acute myocardial infarction (AMI) is a multifaceted syndromeinfluenced by the functions of various extrinsic and intrinsicpathways and pathological processes, which can be detectedin circulation using biomarkers. In this study, we investigatedthe secretome protein profile of induced-hypertrophy cardiomyocytesto identify next-generation biomarkers for AMI diagnosisand management. Hypertrophy was successfully induced inimmortalized human cardiomyocytes (T0445) by 200 nM ET-1and 1 μM Ang II. The protein profiles of hypertrophied cardiomyocytesecretomes were analyzed by nano-liquid chromatographywith tandem mass spectrometry and differentially expressedproteins that have been identified by Ingenuity PathwayAnalysis. The levels of 32 proteins increased significantly(>1.4 fold), whereas 17 proteins (<0.5 fold) showed a rapiddecrease in expression. Proteomic analysis showed significantupregulation of six 14-3-3 protein isoforms in hypertrophiedcardiomyocytes compared to those in control cells. Multi-reactionmonitoring results of human plasma samples showed that14-3-3 protein-zeta levels were significantly elevated in patientswith AMI compared to those of healthy controls. These findingselucidated the role of 14-3-3 protein-zeta in cardiac hypertrophyand cardiovascular disorders and demonstrated its potential asa novel biomarker and therapeutic strategy.

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