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논문 기본 정보

자료유형
학술저널
저자정보
Joonho Moon (GenNBio Co., Ltd.) Su-Jin Kim (GenNBio Co., Ltd.) Jinseok Lee (GenNBio Co., Ltd.) Hyeyoung Kang (GenNBio Co., Ltd.) 조범래 (주식회사 제넨바이오) Sung Joo Kim (GenNBio Co., Ltd.)
저널정보
한국축산학회(구 한국동물자원과학회) 한국축산학회지 Journal of Animal Science and Technology Vol.66 No.1
발행연도
2024.1
수록면
156 - 166 (11page)

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Pigs are genetically, anatomically, and physiologically similar to humans. Recently, pigs are in the spotlight as a suitable source animal for xenotransplantation. However, to use pigs as source animals, pigs should be raised in designated pathogen-free facilities. There is abundant data from embryo transfer (ET) experiments using farm pigs as surrogates, but data on ET experiments using minipigs are scarce. Eighty minipigs were used for ET experiments and after transplantation, the implantation and delivery rates were investigated. It was also confirmed whether the pregnancy rate could be increased by changing the condition or surgical method of the surrogate. In the case of minipigs that gave birth, the size of the fetal sac on the 28th day of ET was also measured. The factors that can affect the pregnancy rate such as estrus synchronization program, ovulation status at the time of ET, the number of repeated ET surgeries, and the ET sites, were changed, and the differences on the pregnancy rate were observed. However there were no significant differences in pregnancy rate in minipigs. The diameter of the implanted fetal sac on the 28th day after ET in the minipigs whose delivery was confirmed was calculated to be 4.7 ± 0.5 cm. In conclusion, there were no significant differences in pregnancy rate of minipigs in the comparative experiment on various factors affecting the pregnancy rate. However, additional experiments and analyses are needed due to the large individual differences of the minipigs.

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