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논문 기본 정보

자료유형
학술저널
저자정보
Moon Sun-In (Chungbuk Environmental Health Center, Chungbuk National University Hospital, Cheongju, Korea.Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, K) Yim Dong-Hyuk (Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea.) Choi Kyunghi (Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea.) Eom Sang-Yong (Chungbuk Environmental Health Center, Chungbuk National University Hospital, Cheongju, Korea.Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, K) Choi Byung-Sun (Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.) Park Jung-Duck (Department of Preventive Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.) Kim Heon (Chungbuk Environmental Health Center, Chungbuk National University Hospital, Cheongju, Korea.Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, K) Kim Yong-Dae (Chungbuk Environmental Health Center, Chungbuk National University Hospital, Cheongju, Korea.Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju, K)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.39 No.8
발행연도
2024.03
수록면
1 - 14 (14page)
DOI
10.3346/jkms.2024.39.e77

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초록· 키워드

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Background: Considering the interactions between heavy metals, a comprehensive evaluation of the effects of exposure to various types of co-interacting heavy metals on health is required. This study assessed the association between dyslipidemia markers and blood mercury, lead, cadmium, iron, zinc, and nickel levels in residents of an abandoned refinery plant. Methods: A total of 972 individuals (exposed group: 567, control group: 405) living near the Janghang refinery plant in the Republic of Korea were included. Blood mercury, lead, cadmium, iron, zinc, nickel, cholesterol, and triglyceride levels were measured. The combined effect of the six heavy metals on dyslipidemia markers was evaluated using a Bayesian kernel machine regression (BKMR) model and compared with the results of a linear regression analysis. The BKMR model results were compared using a stratified analysis of the exposed and control groups. Results: In the BKMR model, the combined effect of the six heavy metals was significantly associated with total cholesterol (TC) levels both below the 45th percentile and above the 55th percentile in the total population. The combined effect range between the 25th and 75th percentiles of the six metals on TC levels was larger in the exposed group than that in the total population. In the control group, the combined effects of the changes in concentration of the six heavy metals on the TC concentration were not statistically significant. Conclusion: These results suggest that the cholesterol levels of residents around the Janghang refinery plant may be elevated owing to exposure to multiple heavy metals.

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