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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 57 - 64 (8page)
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초록· 키워드
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Recently several studies reported that the renal toxicity of lead (Pb) and cadmium (Cd) may exist in even a low level exposure. In terms of the deterioration of tubular function, it affects the loss of divalent metals and leads to other complications, so renal tubular effect of heavy metals should be well managed. Considering the exposure to heavy metals in reality, it is hard to find the case that human is exposed to only one heavy metal. We designed a cross-sectional study using Korean Research Project on the Integrated Exposure Assessment (KRIEFS) data to investigate the renal effects of multiple metal exposure in general population. We used blood Pb and urinary Cd as exposure measures, and urinary N-acetyl-β-D-glucosaminidase (NAG) and β2-microglobulin (β2-MG) as renal tubular impairment outcome. We conducted linear regression to identify the association between each heavy metal and urinary NAG and β2-MG. And then, we conducted linear regression including the interaction term. Of 1953 adults in KRIEFS (2010~2011), the geometric mean of blood Pb and urinary Cd concentration was 2.21 μg/dL (geometric SD = 1.49 μg/dL) and 1.08 μg/g cr (geometric SD = 1.98 μg/g cr), respectively. In urinary Cd, the strength of the association was also high after adjusting (urinary NAG: β = 0.44, p < 0.001; urinary β2-MG: β = 0.13, p = 0.002). Finally, we identified the positive interactions for the two renal biomarkers. The interaction effect of the two heavy metals of β2-MG was greater than that of NAG. It is very important in public health perspective if the low level exposure to multiple heavy metals has an interaction effect on kidney. More epidemiological studies for the interaction and toxicological studies on the mechanism are needed.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Burns, M.S. and Gerstenberger, S.L. (2014) Implications of the new Centers for Disease Control and Prevention blood lead reference value. Am. J. Public Health, 104, e27-33.
Joint FAO/WHO Expert Committee on Food Additives (JECFA). (2010) Evaluation of certain food additives and contaminants (Seventy-first report). WHO Tech. Rep. Ser., 960.
EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain). (2009) Cadmium in food - Scientific opinion of the Panel on Contaminants in the Food Chain. EFSA J., 980, 1-139.
Son, J.Y., Lee, J., Paek, D. and Lee, J.T. (2009) Blood levels of lead, cadmium, and mercury in the Korean population: results from the Second Korean National Human Exposure and Bio-monitoring Examination. Environ. Res., 109, 738- 744.
Korean Centers for Disease Control and Prevention. (2011) 2010 National Health Statistics, Korean National Health and Nutrition Examination Survey (KNHANES). First year.
Joint FAO/WHO Expert Committee on Food Additives (JECFA). (2010) Evaluation of certain food additives and contaminants (Seventy-first report). WHO Tech. Rep. Ser., 960.
EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain). (2009) Cadmium in food - Scientific opinion of the Panel on Contaminants in the Food Chain. EFSA J., 980, 1-139.
Son, J.Y., Lee, J., Paek, D. and Lee, J.T. (2009) Blood levels of lead, cadmium, and mercury in the Korean population: results from the Second Korean National Human Exposure and Bio-monitoring Examination. Environ. Res., 109, 738- 744.
Korean Centers for Disease Control and Prevention. (2011) 2010 National Health Statistics, Korean National Health and Nutrition Examination Survey (KNHANES). First year.
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UCI(KEPA) : I410-ECN-0101-2016-513-002333930