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논문 기본 정보

자료유형
학술저널
저자정보
Kasturi Meghana (Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education) Mathur Vidhi (Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education) Gadre Mrunmayi (Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education) Srinivasan Varadharajan (Manipal Institute of Technology, Manipal Academy of Higher Education) Vasanthan Kirthanashri S. (Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education)
저널정보
한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제21권 제1호
발행연도
2024.1
수록면
21 - 52 (32page)
DOI
10.1007/s13770-023-00576-3

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Fabrication of functional organs is the holy grail of tissue engineering and the possibilities of repairing a partial or complete liver to treat chronic liver disorders are discussed in this review. Liver is the largest gland in the human body and plays a responsible role in majority of metabolic function and processes. Chronic liver disease is one of the leading causes of death globally and the current treatment strategy of organ transplantation holds its own demerits. Hence there is a need to develop an in vitro liver model that mimics the native microenvironment. The developed model should be a reliable to understand the pathogenesis, screen drugs and assist to repair and replace the damaged liver. The three-dimensional bioprinting is a promising technology that recreates in vivo alike in vitro model for transplantation, which is the goal of tissue engineers. The technology has great potential due to its precise control and its ability to homogeneously distribute cells on all layers in a complex structure. This review gives an overview of liver tissue engineering with a special focus on 3D bioprinting and bioinks for liver disease modelling and drug screening.

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