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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.3
- 수록면
- 1 - 11 (11page)
- DOI
- 10.22698/jales.20240001
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The study evaluated the therapeutic effects of resveratrol on experimental autoimmune neuritis (EAN), widely used in the experimental studies of human peripheral demyelinating diseases, including Guillain-Barré syndrome (GBS). EAN was induced in Lewis rats by immunization with a neurogenic peptide homologous to amino acids 53–78 of bovine myelin P2 protein. The rats were monitored daily for clinical symptoms such as paralysis, and the levels of inflammatory mediators were analyzed using immunohistochemistry. The daily oral administration of resveratrol to the EAN-treated rats was observed to significantly reduce the severity of paralysis (p < 0.05). Histopathological examinations additionally confirmed that resveratrol mitigated the inflammation in the sciatic nerves after EAN induction suppressed the infiltration of ionized calcium-binding adaptor molecule-1 positive inflammatory cells, and reduced the number of iNOS-positive inflammatory cells compared to the vehicle-treated group (p < 0.05). Furthermore, the resveratrol-treated group exhibited a decrease in the production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α(p < 0.05). When considered together, these results suggest that resveratrol alleviates neuroinflammation in the sciatic nerves of EAN-induced rats by systemically suppressing circulating pro-inflammatory factors.
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