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논문 기본 정보

자료유형
학술저널
저자정보
Dahee Shim (Hallym University) Yeeun Bak (Hallym University College of Medicine) Han-Gyu Choi (Chungnam National University) Seunghyun Lee (Yonsei University College of Medicine) Sang Chul Park (Hallym University College of Medicine)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.48 No.4
발행연도
2024.7
수록면
354 - 365 (12page)

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초록· 키워드

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Panax species include Panax ginseng Meyer, Panax quinquefolium L., Panax notoginseng, Panax japonicum, Panax trifolium, and Panax pseudoginseng, which contain bioactive components (BCs) such as ginsenosides and polysaccharides. Recently, growing evidence has revealed the pharmacological effects of Panax species and their BCs on allergic airway diseases (AADs), including allergic asthma (AA) and allergic rhinitis (AR). AADs are characterized by damaged epithelium, sustained acquired immune responses with enforced Th2 responses, allergenspecific IgE production, and enhanced production of histamine and leukotrienes by activated mast cells and basophils. In this review, we summarize how Panax species and their BCs modulate acquired immune responses involving interactions between dendritic cells and T cells, reduce the pro-inflammatory responses of epithelial cells, and reduce allergenic responses from basophils and mast cells in vitro. In addition, we highlight the current understanding of the alleviative effects of Panax species and their BCs against AA and AR in vivo. Moreover, we discuss the unmet needs of research and considerations for the treatment of patients to provide basic scientific knowledge for the treatment of AADs using Panax species and their BCs.

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ABSTRACT
1. Introduction
2. In vitro and in vivo immunomodulatory roles of Panax species and their BCs on acquired immune responses
3. In vitro anti-allergic effects of ginsenoside
4. Alleviation of AADs by extracts of Panax species or their BCs
5. Discussion
6. Conclusion
References

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