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논문 기본 정보

자료유형
학술저널
저자정보
Mei Tong He (Gachon University) Byeong Wook Noh (Pusan National University) Hyun Young Kim (Gyeongsang National University) Ah Young Lee (Gyeongsang National University) Eun Ju Cho (Pusan National University)
저널정보
한국생약학회 Natural Product Sciences Natural Product Sciences Vol.30 No.4
발행연도
2024.12
수록면
254 - 261 (8page)
DOI
10.20307/nps.2024.30.4.254

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초록· 키워드

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An excess of amyloid beta (Aβ) led to a rise in ROS production, which in turn caused inflammatory reactions and mitochondrial dysfunction, both of which accelerate the progression of Alzheimer’s disease (AD). Natural flavonoids are proposed as possible agents for neurodegeneration. Pectolinarin is an important flavone mainly found in Cirsium species. In this study, we explored the potential neuroprotective effect of pectolinarin in Aβ<sub>25-35</sub>-induced SH-SY5Y cells. The result demonstrated that pectolinarin enhanced cell viability. Pectolinarin treatment inhibited Aβ<sub>25-35</sub>-induced ROS generation. Pectolinarin also suppressed NO generation by inhibiting the translocation of NF-ĸB and downregulating protein expression of iNOS and COX-2. Moreover, the expression of Bcl-2 increased while BAX protein decreased when the cells were exposed to pectolinarin, resulting in a decrease in the BAX/Bcl-2 ratio. Pectolinarin treatment also increased BDNF and its receptor TrkB protein expression. In conclusion, pectolinarin neuroprotected Aβ<sub>25-35</sub>-induced inflammation and apoptosis. These findings suggest that pectolinarin may be a promising neuroprotective functional food in the protection of the neurodegenerative diseases, including AD.

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Abstract
Introduction
Experimental
Results and Discussion
References

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