지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.12
- 수록면
- 254 - 261 (8page)
- DOI
- 10.20307/nps.2024.30.4.254
이용수
초록· 키워드
오류제보하기
An excess of amyloid beta (Aβ) led to a rise in ROS production, which in turn caused inflammatory reactions and mitochondrial dysfunction, both of which accelerate the progression of Alzheimer’s disease (AD). Natural flavonoids are proposed as possible agents for neurodegeneration. Pectolinarin is an important flavone mainly found in Cirsium species. In this study, we explored the potential neuroprotective effect of pectolinarin in Aβ<sub>25-35</sub>-induced SH-SY5Y cells. The result demonstrated that pectolinarin enhanced cell viability. Pectolinarin treatment inhibited Aβ<sub>25-35</sub>-induced ROS generation. Pectolinarin also suppressed NO generation by inhibiting the translocation of NF-ĸB and downregulating protein expression of iNOS and COX-2. Moreover, the expression of Bcl-2 increased while BAX protein decreased when the cells were exposed to pectolinarin, resulting in a decrease in the BAX/Bcl-2 ratio. Pectolinarin treatment also increased BDNF and its receptor TrkB protein expression. In conclusion, pectolinarin neuroprotected Aβ<sub>25-35</sub>-induced inflammation and apoptosis. These findings suggest that pectolinarin may be a promising neuroprotective functional food in the protection of the neurodegenerative diseases, including AD.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Bioactivities and protective effects of flavonoid pectolinarin in the management of hepatocellular carcinoma: Medicinal importance and therapeutic benefit in the medicine
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .12
-
The Far-Reaching Effects of Neuroinflammation
International Neurourology Journal
2019 .01
-
Evaluation of memory improvement induced by erythritol in a beta-amyloid injection animal model
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Exercise and Neuroinflammation in Health and Disease
International Neurourology Journal
2019 .01
-
Neuroprotective effects of Populus tomentiglandulosa on neurotoxicity in an amyloid beta-induced Alzheimer’s disease mouse
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Beta-amyloid imaging in dementia
영남의대학술지
2018 .01
-
베타아밀로이드로 유도된 신경세포 사멸과 기억력 손상에 대한 밀기울추출물의 보호효과
대한본초학회지(본초분과학회지)
2015 .01
-
The Impact of Autophagy on the Cigarette Smoke Extract-Induced Apoptosis of Bronchial Epithelial Cells
Tuberculosis and Respiratory Diseases
2017 .01
-
Inhibitory Effects of Schisandra chinensis Seed Extracts on Breast Cancer
대한의생명과학회지
2025 .03
-
Galpha12 Protects Vascular Endothelial Cells from Serum Withdrawal-Induced Apoptosis through Regulation of miR-155
Yonsei Medical Journal
2016 .01
-
The Protective Effects of N-Acetyl-L-cysteine on Cadmium-induced Cell Apoptosis in Rat Testis
대한의생명과학회지
2019 .12
-
Amyloid Depositions and Small Vessel Disease in Patients with Cerebral Amyloid Angiopathy: a Case Series
Dementia and Neurocognitive Disorders(대한치매학회지)
2020 .01
-
Long Noncoding RNA MHRT Protects Cardiomyocytes against H<sub>2</sub>O<sub>2</sub>-Induced Apoptosis
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Attenuation of Cognitive Deficits and Brain Pathologies in Alzheimer"s Disease Model by Mixed Mushroom Mycelia
대한체질인류학회 학술대회 연제 초록
2021 .05
-
Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
The Korean Journal of Physiology & Pharmacology
2020 .01
-
아밀로이드 베타로 유발한 알츠하이머병 모델에서 신선초의 기억력 개선 효과
대한본초학회지(본초분과학회지)
2019 .01
-
Regulation of serum amyloid A (SAA) and its association with SAA1-derived amyloid deposition in a hepatic SAA1-overexpression mouse
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Molecular and Cellular Substrates of Neuroinflammation in Alzheimer Disease and Depression
International Neurourology Journal
2019 .01
-
Banhasasim-tang reverse memory deficit and neuroinflammation in lipopolysaccharide-induced mice model
한국실험동물학회 학술발표대회 논문집
2020 .07
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-092174116