지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 417 - 425 (9page)
이용수
초록· 키워드
오류제보하기
Cadmium (Cd) generates reactive oxygen species (ROS), which in turn cause the apoptosis of various cell types including developing germ cells in rodent testis. Ascorbic acids (AA), one of the ROS scavengers, had been reported to protect against Cd-induced apoptosis. N-Acetyl-L-cysteine (NAC), another ROS scavenger, is known to remove ROS and alleviate the Cd-induced apoptosis in various cell types. In this study we tried to elucidate how NAC affected on Cd-induced cell apoptosis in rat testis. Rats were administered with NAC before and after Cd treatment and then testicular cell apoptosis was examined. NAC treatment resulted in the reduction of Cd-induced chromosomal DNA fragmentation in agarose gel electrophoresis. Terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) assay showed that treatment of NAC reduced the Cd-induced apoptosis of germ cells. The administration of NAC showed that the translocation of apoptosis inducing factor (AIF) from mitochondria to nucleus was prevented, which indicated that the mechanism of Cd-induced testicular apoptosis is mediated through the release of AIF in caspase-independent manner. Taken together, the NAC may remove Cd-induced ROS and protect ROS-induced cell apoptosis in rat testis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Acharya UR / 2008 / Effect of vitamin C and E on spermatogenesis in mice exposed to cadmium / Reprod Toxicol 25:84~88
Aldini G / 2018 / N-acetylcysteine as an antioxidant and disulphide breaking agent: the reason why / Free Radic Res 52:751~762
Ates B / 2008 / Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcystein (NAC) / Free Radic Res 42:372~377
Cox B / 2006 / Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics / Nat Protoc 1:1872~1878
Cregan SP / 2004 / Role of AIF in caspasedependent and caspase-independent cell death / Oncogene 23:2785~2796
Aldini G / 2018 / N-acetylcysteine as an antioxidant and disulphide breaking agent: the reason why / Free Radic Res 52:751~762
Ates B / 2008 / Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcystein (NAC) / Free Radic Res 42:372~377
Cox B / 2006 / Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics / Nat Protoc 1:1872~1878
Cregan SP / 2004 / Role of AIF in caspasedependent and caspase-independent cell death / Oncogene 23:2785~2796
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UCI(KEPA) : I410-ECN-0101-2020-510-000240498