지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.2
- 수록면
- 11 - 20 (10page)
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초록· 키워드
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Backgrounds/Aims: The 3-year mortality rate for hepatocellular carcinoma (HCC) in Indonesia was 94.4%. This underscores a sig- nificant health issue in Southeast Asia, particularly in Indonesia due to its large population. This study aimed to characterize the out- comes of liver resection for HCC at a National Referral Center in Indonesia.
Methods: Between 2010 and 2020, all patients with HCC undergoing liver resection were included as subjects. Variables collected in- cluded sex, age, hepatitis status, and tumor’s characteristics. Mortality and survival were the primary outcomes of the study.
Results: Among seventy patients, the mortality rate was 71.4%, with a median overall survival of 19.0 months (95% confidence inter- val [95%CI]: 6.831.2). Thirty-one patients (44.3%) had extra-large HCC tumors (> 10 cm). Those with extra-large tumors had a lower median survival of 8.0 months. Child-Pugh B and Edmonson-Steiner grade 4 were associated with an increased mortality risk, with unadjusted hazard ratios (HRs) of 2.2 (95%CI: 1.14.3, p = 0.026) and 3.2 (95%CI: 1.37.7, p = 0.011), respectively. Multivariate analysis indicated that Child-Pugh class B significantly increased the risk of mortality, with an adjusted HR of 2.3 (95%CI: 1.05.2, p = 0.046).
Conclusions: While surgical resection is feasible for tumors of any size, most clinical features are not statistically significantly associ- ated with survival outcomes. The prevalence of extra-large tumors among Indonesian HCC patients highlights the importance of early diagnosis and intervention. Surgical intervention at an earlier stage and with better grade tumors could potentially enhance survival outcomes.
Methods: Between 2010 and 2020, all patients with HCC undergoing liver resection were included as subjects. Variables collected in- cluded sex, age, hepatitis status, and tumor’s characteristics. Mortality and survival were the primary outcomes of the study.
Results: Among seventy patients, the mortality rate was 71.4%, with a median overall survival of 19.0 months (95% confidence inter- val [95%CI]: 6.831.2). Thirty-one patients (44.3%) had extra-large HCC tumors (> 10 cm). Those with extra-large tumors had a lower median survival of 8.0 months. Child-Pugh B and Edmonson-Steiner grade 4 were associated with an increased mortality risk, with unadjusted hazard ratios (HRs) of 2.2 (95%CI: 1.14.3, p = 0.026) and 3.2 (95%CI: 1.37.7, p = 0.011), respectively. Multivariate analysis indicated that Child-Pugh class B significantly increased the risk of mortality, with an adjusted HR of 2.3 (95%CI: 1.05.2, p = 0.046).
Conclusions: While surgical resection is feasible for tumors of any size, most clinical features are not statistically significantly associ- ated with survival outcomes. The prevalence of extra-large tumors among Indonesian HCC patients highlights the importance of early diagnosis and intervention. Surgical intervention at an earlier stage and with better grade tumors could potentially enhance survival outcomes.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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