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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.8
- 수록면
- 579 - 585 (7page)
- DOI
- 10.1007/s11816-024-00917-1
이용수
초록· 키워드
오류제보하기
RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand) is a cytokine that plays a crucial role in bone remodeling by regulating diferentiation and activation of osteoclast, which breaks down old bone tissue. In this study, we attempted to produce human-derived RANKL using plant expression systems. The RANKL expressed in Nicotiana benthamiana leaves was designed to accumulate within the endoplasmic reticulum lumen. The purifed RANKL from N. benthamiana induced the diferentiation of bone marrow-derived macrophages to mature osteoclast, albeit modestly. In conclusion, human-derived RANKL could be produced using a plant expression system, but it requires further improvement.
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