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논문 기본 정보

자료유형
학술저널
저자정보
Lee Jae-Ho (Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, South Korea) Geem Kyoung Rok (Department of Bioenergy Science and Technology, Chonnam National University, Gwangju 61186, South Korea) Chen Zhihao (Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, South Korea) Jeong Jujin (Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, South Korea) Park Sang-Wook (Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, South Korea) Lee Dong Wook (Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, South Korea)
저널정보
한국식물생명공학회 Plant Biotechnology Reports Plant Biotechnology Reports Vol.18 No.4
발행연도
2024.8
수록면
579 - 585 (7page)
DOI
10.1007/s11816-024-00917-1

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RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand) is a cytokine that plays a crucial role in bone remodeling by regulating diferentiation and activation of osteoclast, which breaks down old bone tissue. In this study, we attempted to produce human-derived RANKL using plant expression systems. The RANKL expressed in Nicotiana benthamiana leaves was designed to accumulate within the endoplasmic reticulum lumen. The purifed RANKL from N. benthamiana induced the diferentiation of bone marrow-derived macrophages to mature osteoclast, albeit modestly. In conclusion, human-derived RANKL could be produced using a plant expression system, but it requires further improvement.

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