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논문 기본 정보

자료유형
학술저널
저자정보
Kai Korekawa (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) Yusuke Shimoyama (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) Fumiyoshi Fujishima (Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan) Hiroshi Nagai (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) Takeo Naito (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) Rintaro Moroi (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) Hisashi Shiga (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) Yoichi Kakuta (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan) Yoshitaka Kinouchi (Student Healthcare Center, Institute for Excellence in Higher Education, Tohoku University, Sendai, Japan) Atsushi Masamune (Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan)
저널정보
대한소화기내시경학회 Clinical Endoscopy Clinical Endoscopy Vol.57 No.5
발행연도
2024.9
수록면
637 - 646 (10page)
DOI
10.5946/ce.2024.027

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Background/Aims: During endoscopy, white spots (WS) are sometimes observed around benign or malignant colorectal tumors; however, few reports have investigated WS, and their significance remains unknown. Therefore, we investigated the significance of WS from clinical and pathological viewpoints and evaluated its usefulness in endoscopic diagnosis. Methods: Clinical data of patients with lesions diagnosed as epithelial tumors from January 1, 2019, to December 31, 2020, were analyzed (n=3,869). We also performed a clinicopathological analysis of adenomas or carcinomas treated with endoscopic resection (n=759). Subsequently, detailed pathological observations of the WS were performed. Results: The positivity rates for WS were 9.3% (3,869 lesions including advanced cancer and non-adenoma/carcinoma) and 25% (759 lesions limited to adenoma and early carcinoma). Analysis of 759 lesions showed that the WS-positive lesion group had a higher proportion of cancer cases and larger tumor diameters than the WS-negative group. Multiple logistic analysis revealed the following three statistically significant risk factors for carcinogenesis: positive WS, flat lesions, and tumor diameter ≥5 mm. Pathological analysis revealed that WS were macrophages that phagocytosed fat and mucus and were white primarily because of fat. Conclusions: WS are cancer-related findings and can become a new criterion for endoscopic resection in the future.

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