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논문 기본 정보

자료유형
학술저널
저자정보
Se Hyun Kim (Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea) Do-Un Jung (Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea) Do Hoon Kim (Department of Psychiatry, Chuncheon Sacred Heart Hospital & Mind-Neuromodulation Laboratory, Hallym University College of Medicine, Chuncheon, Republic of Korea) Jung Sik Lee (Lee Jung Sik Psychiatric Clinic, Suwon, Republic of Korea) Kyoung-Uk Lee (Department of Psychiatry, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, Republic of Korea) Seunghee Won (Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea) Bong Ju Lee (Department of Psychiatry, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea) Sung-Gon Kim (Department of Psychiatry, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea) Sungwon Roh (Department of Psychiatry, Hanyang University College of Medicine, Seoul, Republic of Korea) Jong-Ik Park (Department of Psychiatry, Kangwon National University School of Medicine, Chuncheon, Republic of Korea) Minah Kim (Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea) Sung Won Jung (Department of Psychiatry, Keimyung University DongSan Hospital, Daegu, Republic of Korea) Hong Seok Oh (Department of Psychiatry, Konyang University Hospital, Daejeon, Republic of Korea) Han-yong Jung (Department of Psychiatry, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea) Sang Hoon Kim (Dajeonghan Hospital, Naju, Republic of Korea) Hyun Seung Chee (Department of Psychiatry, Chungnam National University Hospital, Daejeon, Republic of Korea) Jong-Woo Paik (Department of Neuropsychiatry, Kyung Hee University College of Medicine, Seoul, Republic of Korea) Kyu Young Lee (Department of Psychiatry, Eulji General Hospital, Seoul, Republic of Korea) Soo In Kim (Department of Psychiatry, Ewha Womans University College of Medicine, Seoul, Republic of Korea) Seung-Hwan Lee (Clinical Emotion and Cognition Research Laboratory, Goyang, Republic of Korea) Eun-Jin Cheon (Department of Psychiatry, Yeungnam University Hospital, Daegu, Republic of Korea) Hye-Geum Kim (Department of Psychiatry, Yeungnam University Hospital, Daegu, Republic of Korea) Heon-Jeong Lee (Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea) In Won Chung (Yong-In Mental Hospital, Yongin, Korea) Joonho Choi (Department of Psychiatry, Hanyang University Guri Hospital, Guri, Republic of Korea) Min-Hyuk Kim (Department of Psychiatry, Wonju Severance Christian Hospital, Wonju, Republic of Korea) Seong-Jin Cho (Department of Psychiatry, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea) HyunChul Youn (Department of Psychiatry, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea) Jhin-Goo Chang (Department of Psychiatry, Myongji Hospital, Hanyang University College of Medicine, Goyang, Republic of Korea) Hoo Rim Song (Department of Psychiatry, Myongji Hospital, Hanyang University College of Medicine, Goyang, Republic of Korea) Euitae Kim (Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea) Won-Hyoung Kim (Department of Psychiatry, Inha University Hospital, Incheon, Republic of Korea) Chul Eung Kim (NCMH, Mental Health Research Institute, Seoul, Republic of Korea) Doo-Heum Park (Department of Psychiatry, Konkuk University Medical Center, Seoul, Republic of Korea) Byung-Ook Lee (Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea) Jungsun Lee (Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea) Seung-Yup Lee (Department of Psychiatry, Eunpyeong St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea) Nuree Kang (Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea) Hee Yeon Jung (Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea)
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION Vol.21 No.7
발행연도
2024.7
수록면
762 - 771 (10page)

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초록· 키워드

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Objective This study was performed to evaluate the efficacy and safety of lurasidone (160 mg/day) compared to quetiapine XR (QXR; 600 mg/day) in the treatment of acutely psychotic patients with schizophrenia. Methods Patients were randomly assigned to 6 weeks of double-blind treatment with lurasidone 160 mg/day (n=105) or QXR 600 mg/ day (n=105). Primary efficacy measure was the change from baseline to week 6 in Positive and Negative Syndrome Scale (PANSS) total score and Clinical Global Impressions severity (CGI-S) score. Adverse events, body measurements, and laboratory parameters were assessed. Results Lurasidone demonstrated non-inferiority to QXR on the PANSS total score. Adjusted mean±standard error change at week 6 on the PANSS total score was -26.42±2.02 and -27.33±2.01 in the lurasidone and QXR group, respectively. The mean difference score was -0.91 (95% confidence interval -6.35–4.53). The lurasidone group showed a greater reduction in PANSS total and negative subscale on week 1 and a greater reduction in end-point CGI-S score compared to the QXR group. Body weight, body mass index, and waist circumference in the lurasidone group were reduced, with significantly lower mean change compared to QXR. Endpoint changes in glucose, cholesterol, triglycerides, and low-density lipoprotein levels were also significantly lower. The most common adverse drug reactions with lurasidone were akathisia and nausea. Conclusion Lurasidone 160 mg/day was found to be non-inferior to QXR 600 mg/day in the treatment of schizophrenia with comparable efficacy and tolerability. Adverse effects of lurasidone were generally tolerable, and beneficial effects on metabolic parameters can be expected.
#Lurasidone #Efficacy #Safety #Randomized clinical trial

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