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논문 기본 정보

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학술저널
저자정보
Rahiya Rehman (Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Hasbro Children’s Hospital and Department of Pediatrics, Warren Alpert Medical School of Brown University) Muhammad Safwan Riaz (Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Hasbro Children’s Hospital and Department of Pediatrics, Warren Alpert Medical School of Brown University) Dyadin Esharif (Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Hasbro Children’s Hospital and Department of Pediatrics, Warren Alpert Medical School of Brown University) Phinnara Has (Lifespan Biostatistics, Epidemiology and Research Design, Rhode Island Hospital, Providence, RI, USA) Michael Herzlinger (Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Hasbro Children’s Hospital and Department of Pediatrics, Warren Alpert Medical School of Brown University) Jason Shapiro (Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Hasbro Children’s Hospital and Department of Pediatrics, Warren Alpert Medical School of Brown University) Shova Subedi (Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Hasbro Children’s Hospital and Department of Pediatrics, Warren Alpert Medical School of Brown University)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.22 No.3
발행연도
2024.7
수록면
351 - 356 (6page)
DOI
10.5217/ir.2023.00091

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Background/Aims: To describe the role of ustekinumab in inducing remission and endoscopic healing in anti-tumor necrosis factor α nonresponsive pediatric ulcerative colitis patients at a tertiary care inflammatory bowel disease center. Methods: A retrospective chart review was performed on patients with ulcerative colitis receiving ustekinumab. Primary outcome was steroidfree clinical remission at follow-up. Secondary outcomes were biochemical remission and endoscopic healing. Results: Ten children were analyzed; 7 (70%) had ulcerative colitis, and 3 (30%) had inflammatory bowel disease unspecified with colitis. Median follow-up period was 56 weeks. Nine patients (90%) achieved steroid-free clinical remission and biochemical remission. Seven patients had follow-up colonoscopies, out of which 6 (86%) achieved endoscopic remission, while 1 (14%) underwent colectomy. Out of the 3 patients without a follow-up colonoscopy, fecal calprotectin levels downtrended to < 150 mg/kg in 2 patients and < 400 mg/kg in 1 patient from baseline level of > 2,000 mg/kg. Conclusions: Ustekinumab appears efficacious in achieving not only clinical and biochemical remission but also has promising role in inducing endoscopic healing end point in patients who fail other biologics.

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