지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition Vol.27 No.4
- 발행연도
- 2024.7
- 수록면
- 224 - 235 (12page)
- DOI
- 10.5223/pghn.2024.27.4.224
이용수
초록· 키워드
오류제보하기
Purpose: Biliary atresia (BA) is the leading cause of neonatal cholestasis (25–45%). The primary treatment is hepatic portoenterostomy (Kasai procedure), but only 20–40% provide long-term benefits. This study aimed to develop a predictive model for surgical efficacy by comparing preoperative and early postoperative indicators in infants with different outcomes.
Methods: We enrolled 166 infants with BA (93 girls, 73 boys) who underwent the Kasai procedure between September 2002 and December 2021, dividing them into favorable or adverse outcome groups. Over 40 parameters were measured, and the diagnostic significance of the prognostic model was evaluated.
Results: Kasai surgery was efficacious in 69 patients (42%) and non-efficacious in 97 (58%).
Our model assesses efficacy by day 14 after surgery, improving on the <34 μmol/L direct bilirubin threshold established for 3–6 months after the procedure. Including the Desmet fibrosis score refined the model.
Conclusion: Blood cholesterol below 5.41 mmol/L, direct bilirubin below 56.3 μmol/L on postoperative days 14±3, and a low Desmet score indicate a high probability of efficacious Kasai surgery in infants with BA.
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