지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.7
- 수록면
- 1 - 10 (10page)
- DOI
- https://doi.org/10.3802/jgo.2024.35.e38
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초록· 키워드
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Objective: Patients with ovarian cancer have a high risk of developing thrombosis. We aimedto investigate laborator y parameters associated with deep vein thrombosis (DVT) in patientstreated for ovarian cancer.
Methods: We retrospectively analyzed pre-operation laborator y data of patients withovarian cancer for DVT at the National Cancer Center, Korea, between Januar y 2000 andFebruar y 2021. The test items were white blood cell count, absolute neutrophil count (ANC),hemoglobin, platelets, monocytes, serum glucose, CA125, D-dimer, fibrinogen, prothrombintime (PT), activated partial thromboplastin time (aPTT), and body mass index (BMI).
Differences between patients with and without DVT were compared with Wilcoxon rank-sumtest. We analyzed the variables using logistic regression. Items with significant odds ratioswere included in multivariate logistic regression. Significant variables were selected usingbackward elimination. Items were further categorized based on reference ranges. Univariateand multivariate analyses were performed to identif y items with abnormal values associatedwith DVT.
Results: From 3,147 patient samples analyzed, 286 (9.1%) patients with DVT were selected.
Differences between patients with vs without DVT were statistically significant forhemoglobin, monocyte, serum glucose, CA125, PT, aPTT, fibrinogen, D-dimer, and BMI.
After univariate and multivariate analysis, monocyte, glucose, and PT remained significant.
Among the categorical variables, low hemoglobin, high monocyte, high CA125, prolongedPT, and high BMI remained significant after univariate and multivariate analysis.
Conclusion: Pre-operation laborator y data of low hemoglobin, high monocyte percentage,high serum glucose, high CA125, prolonged PT, and high BMI were associated with DVT.
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