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논문 기본 정보

자료유형
학술저널
저자정보
Park Young Shil (Department of Pediatrics, Kyunghee University Hospital at Gandong, Seoul, Republic of Korea) Yoo Ki-Young (Korea Hemophilia Foundation Clinic, Seoul, Republic of Korea) Park Sang Kyu (Korea Hemophilia Foundation Clinic, Busan, Republic of Korea) Hwang Tai ju (Korea Hemophilia Foundation Clinic, Gwangju, Korea) Jung Aeran (Medical Affairs, Takeda Pharmaceuticals Korea Co., Ltd, Seoul, Republic of Korea) Choi Eun Jin (Department of Pediatrics, Daegu Catholic University Medical Center, Daegu, Korea)
저널정보
대한혈액학회 Blood Research Blood Research Vol.59 No.3
발행연도
2024.9
수록면
29 - 29 (1page)
DOI
10.1007/s44313-024-00023-9

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초록· 키워드

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This study aimed to investigate the pharmacokinetics (PK) of factor VIII (FVIII) in Korean patients, as limited information is available on the PK of FVIII in this population.We collected the FVIII PK results from patients with moderate-to-severe hemophilia A using myPKFiT. PK variations were assessed according to age, blood type, inhibitor history, von Willebrand factor antigen (vWF:Ag) level, and body mass index. Additionally, the correlation between the PK profile and prophylaxis regimen was specifically analyzed for each product in severe cases.The PK data of 48 and 81 patients treated with octocog alfa and rurioctocog alfa pegol, respectively, were obtained. The median half-lives of octocog alfa and rurioctocog alfa pegol were 9.9 (range: 6.3–15.2) h and 15.3 (range: 10.4–23.9) h, respectively. The PK profiles for each product did not differ according to age group; however, blood type-O patients had shorter half-lives and time to 1% compared to non-blood type-O patients. In regression analysis, the PK of octocog alfa showed a statistically significant difference according to age, whereas the PK of rurioctocog alfa pegol correlated with vWF:Ag. Only the frequency of rurioctocog alfa pegol use showed a statistically significant difference in relation to time to 1%, although the coefficient of determination was small.This study confirmed significant interpatient variation in the PK of FVIII among Korean patients with hemophilia A. To achieve optimized prophylaxis, personalizing the regimen based on the PK profile of each individual patient is essential.

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