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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 271 - 273 (3page)
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Escherichia coli can harbor genomic pks islands that code for a polyketide-peptide genotoxin known as colibactin. E. coli strains carrying pks islands trigger genetic instability. pks islands have been significantly associated with bacteremia. We investigated the molecular epidemiology of bacteremic E. coli isolates and the prevalence of bacteremia-causing E. coli carrying pks islands. A total of 146 E. coli isolates were collected at a tertiary-care hospital from January 2015 to December 2016. The phylogenetic groups were determined by multiplex PCR. All isolates were screened by PCR for sequence type 131 (ST131)-associated single-nucleotide polymorphisms (SNPs) in mdh and gyrB. For detection of pks islands, we performed PCR for the clbB and clbN genes as colibactin system markers. Phylogenetic group B2 was the most common, accounting for 54.1% (N=79) of the isolates, followed by group D with 29.5% (N=43), group A with 11.6% (N=17), and group B1 with 4.8%. Of the group B2 isolates, 40.5% were ST131 strains and 32.9% carried pks islands. Only three ST131 isolates in group B2 carried the clbB and clbN genes, while the other 23 ST131 isolates did not. The pks gene might not be associated with ST131 strains.
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참고문헌 (10)
참고문헌 신청
Bonacorsi S / 2006 / Comparative prevalence of virulence factors in Escherichia coli causing urinary tract infection in male infants with and without bacteremia / J Clin Microbiol 44:1156~1158
Wang MC / 2002 / The role of bacterial virulence and host factors in patients with Escherichia coli bacteremia who have acute cholangitis or upper urinary tract infection / Clin Infect Dis 35:1161~1166
Cuevas-Ramos G / 2010 / Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells / Proc Natl Acad Sci USA 107:11537~11542
Johnson JR / 2008 / Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island / J Clin Microbiol 46:3906~3911
CLSI / 2015 / Performance standards for antimicrobial susceptibility testing. 25th ed. CLSI document M100-S25 / Clinical and Laboratory Standards Institute
Wang MC / 2002 / The role of bacterial virulence and host factors in patients with Escherichia coli bacteremia who have acute cholangitis or upper urinary tract infection / Clin Infect Dis 35:1161~1166
Cuevas-Ramos G / 2010 / Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells / Proc Natl Acad Sci USA 107:11537~11542
Johnson JR / 2008 / Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island / J Clin Microbiol 46:3906~3911
CLSI / 2015 / Performance standards for antimicrobial susceptibility testing. 25th ed. CLSI document M100-S25 / Clinical and Laboratory Standards Institute
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