지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.30 No.1
- 발행연도
- 2025.2
- 수록면
- 47 - 55 (9page)
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Sarcopenia refers to the loss of muscle mass with age, significantly impacting the lives of the elderly. Fingerroot [Boesenbergia pandurata (Roxb.) Schltr.] exhibits antioxidant, anti-inflammatory, antibacterial, and anti-obesity activities. In this study, we demonstrated the inhibitory effect of fingerroot extract (B. pandurata extract, BPE) standardized with panduratin A on sarcopenia in aged rats. The results showed that BPE significantly increased the weights of the gastrocnemius and tibialis anterior muscle tissues and the cross-sectional area of the muscle fibers. In addition, BPE activated the phosphoinositide 3-kinase/Akt pathway, thereby activating the mammalian target of rapamycin pathway for protein formation and inhibiting proteolysis by decreasing forkhead box O3a-mediated muscle-specific ubiquitin ligases. BPE not only reduced tumor necrosis factor alpha and interleukin-6 levels but also stimulated the activities and mRNA expression of catalase and superoxide dismutase. The results suggest that BPE can be used as a functional food ingredient to inhibit or decelerate sarcopenia progression.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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