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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.3
- 수록면
- 55 - 61 (7page)
- DOI
- 10.20307/nps.2025.31.1.55
이용수
초록· 키워드
오류제보하기
The ability of androst-16-ene-3,6-diol, a compound derived from Lysimachia christinae, to enhance cognitive function was assessed in mice with scopolamine-induced amnesia. through behavioral and biochemical studies. The Morris water maze test demonstrated significant improvements in spatial learning and memory, with treated mice showing reduced escape latency, shorter path lengths, and enhanced swimming trajectories compared to scopolamine-treated controls. In the passive avoidance test, androst-16-ene-3,6-diol effectively restored retention memory, getting about 65% of the performance detected in control mice group. Biochemical analysis revealed that androst-16-ene-3,6-diol notably diminished acetylcholinesterase activity in the cortex and hippocampus, critical regions for learning and memory. These effects were comparable to those of donepezil, a standard acetylcholinesterase inhibitor used as a positive control (1 mg/kg orally). The findings indicate that androst-16-ene-3,6-diol exerts robust cognitive-enhancing effects by mitigating scopolamine-induced cholinergic deficits through acetylcholinesterase inhibition. This highlights its potential as a promising therapeutic candidate for memory impairment and neurodegenerative disorders.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
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