지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.3
- 수록면
- 62 - 73 (12page)
- DOI
- 10.20307/nps.2025.31.1.62
이용수
초록· 키워드
오류제보하기
The roots of Astragalus membranaceus Bunge have long been used in herbal medicine for their diverse biological activities. Notably, its potential anti-diabetic properties have been extensively studied, highlighting promising therapeutic prospects. In this study, we conducted a comprehensive investigation focusing on flavonoid components from the roots of A. membranaceus and their PTP1B inhibitory activity. As a result, we isolated a total of 24 flavonoids, among which formonentin (1), pratensein (3), and vesticarpan (19) emerged as the most potent inhibitors against PTP1B with IC<sub>50</sub> value of 10.9 ± 1.09 μM, 10.0 ± 1.71 μM, and 10.3 ± 1.31 μM, respectively. Additionally, through the enzyme kinetic analysis, the inhibition mode of compound 19 was determined as a competitive inhibitor, with K<sub>i </sub>value of 7.6 ± 1.17 μM. Furthermore, the molecular docking simulation elucidated the binding mechanism of compound 19 with PTP1B, mainly through van der Waals forces and hydrogen bonds. This study highlights the PTP1B inhibitory potential of the flavonoid constituents derived from the roots of A. membranaceus. Moreover, discovering vesticarpan (19) as a novel PTP1B inhibitor provides a significant foundation for further investigations to develop innovative therapeutic strategies for diabetes treatment.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Inhibitory Activity of PTP1B and α-Glucosidase by Compounds from Whole Plants of Houttuynia cordata Thunb
Natural Product Sciences
2023 .12
-
The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A
Blood Research
2019 .01
-
Implications of Alterations in Pre-test Probability in the 2019 Update of ESC Guidelines for Chronic Coronary Syndromes on Diagnostic Accuracy of Pharmacological Stress-Echocardiography: A Retrospective Cohort Study
Journal of Cardiovascular Imaging
2021 .01
-
Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation
Journal of Ginseng Research
2023 .03
-
참두릅 잎의 Protein Tyrosine Phosphatase 1B와 α-Glucosidase 저해 활성
생약학회지(Korean Journal of Pharmacognosy)
2016 .03
-
Effect of Puffing in the Extraction of Active Ingredients from the Roots of Paeonia lactiflora and Astragalus membranaceus
Natural Product Sciences
2022 .06
-
Ferulate, an Active Component of Wheat Germ, Ameliorates Oxidative Stress-Induced PTK/PTP Imbalance and PP2A Inactivation
Toxicological Research
2018 .10
-
In Silico Analysis of Potential Antidiabetic Phytochemicals from Matricaria chamomilla L. against PTP1B and Aldose Reductase for Type 2 Diabetes Mellitus and its Complications
Natural Product Sciences
2021 .06
-
黃芪 추출물의 외용 도포가 자발성 원형탈모 생쥐에 미치는 영향
대한한의학회지
2018 .03
-
Hepatoprotective effects of an herbal composition, MAP, a standardized blend comprising myristica fragrans, Astragalus membranaceus, and Poria cocos against alcohol-induced liver injury in mice
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Development and Validation of an HPLC-PDA Method for Quantitation of Ten Marker Compounds from Eclipta prostrata (L.) and Evaluation of Their Protein Tyrosine Phosphatase 1B, α-Glucosidase, and Acetylcholinesterase Inhibitory Activities
Natural Product Sciences
2020 .12
-
갑상선 절제 술 후 기능적 음성장애의 공기역학적 특징과 음성치료 중재
대한후두음성언어의학회지
2015 .01
-
Flavonoids over women’s health: a literature review
Journal of Biomedical and Translational Research
2018 .06
-
Endothelial PTP mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Inhibitory Aromatase Effects of Flavonoids from Ginkgo Biloba Extracts on Estrogen Biosynthesis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
네트워크 약리학을 통한 당뇨병성 신병증에서의 황기와 산수유의 활성 성분 및 잠재 타겟 예측
동의생리병리학회지
2017 .01
-
네트워크 약리학을 통한 당뇨병성 신병증에서의 황기와 산수유의 활성 성분 및 잠재 타겟 예측
동의생리병리학회지
2017 .12
-
Flavonoids as anti-inflammatory and neuroprotective agents
International Journal of Oral Biology
2020 .01
-
황기의 연근 별 성분과 생리 활성에 미치는 영향
대한한의학방제학회지
2018 .01
-
Flavonoids: Broad Spectrum Agents on Chronic Inflammation
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0