지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.6
- 수록면
- 91 - 98 (8page)
이용수
초록· 키워드
오류제보하기
Alkylating agents form alkylated base adducts in the DNA and cause DNA lesions leading to cell killing. In this study, we investigated the mechanism of apoptosis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in PC-3 and DU145 human prostate carcinoma cell lines. MNNG treatment resulted in the inhibition of cell proliferation in a concentration-dependent manner to a similar
extent in both cell lines. This anti-proliferative effect of PC-3 and DU145 cells by MNNG was associated with morphological changed such as membrane shrinking, cell rounding up and formation of
apoptotic bodies. MNNG treatment also induced a proteolytic cleavage of specific target proteins such as poly(ADP-ribose) polymerase (PARP) and b-catenin proteins in DU145 cells but in PC-3 cells. Furthermore, we observed an increase of pro-apoptotic protein Bax family expression and a decrease of anti-apoptotic protein Bcl-2 family by MNNG treatment in a concentration-dependent manner. MNNG also induced a proteolytic activation of caspase-3 and -9, which is believed to play a central role in the apoptotic signaling pathway.
extent in both cell lines. This anti-proliferative effect of PC-3 and DU145 cells by MNNG was associated with morphological changed such as membrane shrinking, cell rounding up and formation of
apoptotic bodies. MNNG treatment also induced a proteolytic cleavage of specific target proteins such as poly(ADP-ribose) polymerase (PARP) and b-catenin proteins in DU145 cells but in PC-3 cells. Furthermore, we observed an increase of pro-apoptotic protein Bax family expression and a decrease of anti-apoptotic protein Bcl-2 family by MNNG treatment in a concentration-dependent manner. MNNG also induced a proteolytic activation of caspase-3 and -9, which is believed to play a central role in the apoptotic signaling pathway.
목차
ABSTRACT
서론
재료 및 방법
결과 및 고찰
결론
감사의 말씀
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Gene Expression Analysis from the Normal Stomach Cells Treated with a Cancer Inducer N-methyl-N"-nitro-N-nitrosoguanidine, MNNG
대한의생명과학회지
2017 .03
-
산화적 스트레스에 의한 N'-methyl-N'-nitroguanidine의 유전독성증가
Environmental Analysis Health and Toxicology
2007 .12
-
Gene Expression Profiling of Genotoxicity Induced by MNNG in TK6 Cell
Molecular & cellular toxicology
2007 .01
-
Anticlastogenic Effects of Galangin against N-Methyl-N′-nitro-N-nitrosoguanidine-induced Micronuclei in Bone-marrow Cells of C57BL/6 Mice
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1993 .01
-
N - Methy - N Nitro - N - Nitroguanidine에 의한 Adenovirus Type 12 Transformation의 증진
JOURNAL OF BACTERIOLOGY AND VIROLOGY
1997 .12
-
Capsaicin-Induced Apoptosis of FaDu Human Pharyngeal Squamous Carcinoma Cells
Yonsei Medical Journal
2012 .01
-
어성초 메탄올 추출물에 의한 A549 인체 폐암세포 사멸유도에 관한 연구
동의생리병리학회지
2006 .01
-
Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
비소화합물에 의한 A549 폐암세포의 증식억제에 관한 연구
동의생리병리학회지
2005 .01
-
Effect of Mirtazapine on MNNG-Induced Gastric Adenocarcinoma in Rats
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Induction of Ornithine Decarboxylase and Tumor Promotion by N-Methyl-N′-Nitro-N-Nitrosoguanidine, Sodium Chloride, and Dimethyl Itaconate
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1993 .01
-
Expression of Bcl-2 and Caspase-3 Proteins Related to Apoptosis in Human Leukemia K-562 Cells
대한의생명과학회지
2005 .09
-
인체 혈구암세포에 대한 丹仙湯 추출물의 증식억제 및 세포사멸 유도에 관한 연구
대한한방내과학회지
2011 .01
-
Melittin Inhibits Human Prostate Cancer Cell Growth through Induction of Apoptotic Cell Death
Toxicological Research
2006 .03
-
전립선 암세포에서 silymarin의 고사 유도 효과 및 기전 연구
동의생리병리학회지
2005 .01
-
Human Neuroblastoma Cell Line BE2에 대한 健脾補腎抗癌湯의 세포고사 기전 연구
대한한방내과학회지
2006 .01
-
Galangin의 MNNG 또는 Bleomycin유도 염색체 손상에 대한 억제효과
한국응용약물학회 신약개발 연구발표회
1993 .01
-
전립선 암세포주 DU145의 세포고사 유도를 통한 신선초 (Angelica keiskei) 메틸렌 클로라이드 추출물의 항암효과
대한암한의학회지
2010 .01
-
Overexpression of Bcl-2 protects differentiated PC12 cells against beta amyloid- induced apoptosis through inhibition of NF-kB and p38 MAP kinase activation
대한약학회 학술대회
2003 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-513-013746206