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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1999.6
- 수록면
- 177 - 181 (5page)
이용수
초록· 키워드
오류제보하기
Cultured human skin cells are a potentially useful method for skin irritancy testing. We have evaluated the effects of humectants on human dermal fibroblasts. Cell viability assessed by the neutral red uptake (NRU) assay and Alamar Blue (AB) assay was carried out in a dose dependent manner. The irritation potential of humectants by human skin patch test was assessed as in vivo methods. There was a relatively good correlation between the in vitro responses and human patch test scores for the humectants tested. The correlation of the in vitro NRU assay data on the basis of lC50 values with human patch test data yielded a correlation coefficient of r=0.66. The correlation of the in vitro AB assay data on the basis of lC50 values with in vivo data yielded a correlation coefficient of r=0.60. The correlation of the in vitro NRU assay data on the basis of lC10 values with human patch test data yielded a correlation coefficient of r=0.71I. The correlation of the in vitro AB assay data on the basis of lC80 values with in vivo data yielded a correlation coefficient of r=0.77. Our result suggest that AB and NRU assay using cultured human fibroblast could be relatively predictable methods for the irritancy of various humectants in humans.
목차
ABSTRACT
Ⅰ. INTRODUCTION
Ⅱ. MATERIALS AND METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
ACKNOWLEDGEMENT
REFERENCES
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