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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.3 No.2
- 발행연도
- 1998.6
- 수록면
- 163 - 168 (6page)
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초록· 키워드
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Inhibitory effect of indole oligomers induced from indole-3-carbinol (I3C) on the growth of breast cancer cells was studied. We generated the reaction mixtures (RXM) at ambient temperature by treating a stirred aqueous solution of I3C (typically 0.25 ml at a concentration of 12μmol/ml) with hydrochloric acid (typically 28μl of a 1 mmol/ml solution). RXM was fractionated by the column chromatography. The fractions with similar UV -pattern were further fractionated by HPLC and 3,3'-diindoylmethane (DIM) and other indole oligomers were identified. I3C, RXM, and its derived indole compounds were added to MCF-7 cells and cultured in the presence of 10^(-7)M estradiol for 7 days. The growth-inhibitory effect of I3C and DIM on the growth of MCF-7 cell was very strong. The synthetic DIM also revealed antiproliferative effect on MCF-7 cell. The fractions containing high DIM content (77%), were most effective in inhibiting MCF-7 cell growth induced by estradiol. With these results, we suggest that I3C and DIM might have anticarcinogenic effect on the breast cancer.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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