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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.9
- 수록면
- 275 - 279 (5page)
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It is demonstrated that cadmium has cytotoxic effect on glial cells, oxygen radicals are involved in cadmium-induced cytotoxicity. However, the toxic mechanism of cadmium is left unknown so far. The purpose of this study was to examine the cytotoxicity of CdCl<SUB>2</SUB> on C<SUB>6</SUB> glioma cells. The cytotoxicy was measured by cell viability via XTT assay in C<SUB>6</SUB> glioma cells. Colorimetric assay such as XTT assay is regarded as a very sensitive screening method for the determination of the cell viability on a lots of chemicals. In this study, CdCl<SUB>2</SUB> decreased cell viability according to the dose- and time dependent manners after C<SUB>6</SUB> glioma cells were treated with various concentrations of CdCl<SUB>2</SUB> for 48 hours. IC<SUB>90</SUB> and IC<SUB>50</SUB> values for XTT assay was determined at 5 μM and 55 μM of CdCl<SUB>2</SUB>, respectively. These results suggest that CdCl<SUB>2</SUB> has highly cytotoxic effect on C<SUB>6</SUB> glioma cells by the decrease of cell viability.
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