1,2-Dimethylhydrazine에 의해 유발된 Colonic Aberrant Crypt Foci에 대한 마늘추출물의 암예방효과

김태명; 류재면; 권현정; 황인국; 반정옥; 정헌상; 홍진태; 김대중

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자료유형: 학술저널

저자정보: 김태명 류재면 권현정 황인국 반정옥 정헌상 홍진태 김대중

저널정보: 한국독성학회 Toxicological Research Journal of Toxicology and Public Health Vol.23 No.4

발행연도: 2007.12

수록면: 321 - 330 (10page)

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2007

1,2-Dimethylhydrazine에 의해 유발된 Colonic Aberrant Crypt Foci에 대한 마늘추출물의 암예방효과

김태명 , 류재면 , 권현정 외 5명 Toxicological Research 2007.12 학술저널

2005

1,2-Dimethylhydrazine에 의해 유발된 Colonic Aberrant Crypt Foci에 대한 마늘 에탄올 추출물의 암예방효과

김태명 , 류재면 , 권현정 외 3명 한국실험동물학회 학술발표대회 논문집 2005.06 학술대회자료

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Garlic (Allium sativum L.) with the food supplement material and medicine was used traditionally in Asia and Europe. Epidemiological studies revealed that the intake of garlic reduced incidences of various cancer including digestive system. The present study was designed to investigate the effect of garlic ethanol extract on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) in male F344 rats. Five-week-old rats were given four times for two weeks to subcutaneous injections by DMH (30 ㎎/㎏ body weight) to induce ACF. The animals were divided into groups that fed diet containing garlic ethanol extract at five different doses (0.1, 0.2, 0.5, 2, 5%), respectively, animals were evaluated for the total number of ACF and total aberrant crypts (AC) per colon detected from methylene blue-stained rat colon. ACF were formed in animals in DMH-treated group. The feeding suppressed potently the appearance ACF in the colon of rats. Especially, fed diet containing garlic ethanol extract at intermediate dose (0.5%) significantly reduced the number of ACF and AC per colon (p ＜ 0.05). Garlic ethanol extract inhibited DMH-induced overexpression of Activator Protein-1 (AP-1) and β-catenin genes related to cell proliferation that also upregulated the expression of p21Waf1/Cip1 mRNA, a cell cycle-regulating gene. These results suggested that garlic ethanol extract may inhibit ACF formation, β-catenin gene as the early preneoplastic marker of malignant potential in the process of colon carcinogenesis.

#Garlic #Aberrant crypt foci(ACF) #1, 2-Dimethylhydrazine(DMH) #Colon carcinogenesis

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