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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 227 - 233 (7page)
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The chemopreventive effects of Magnolia ovobata water extract (MWE) and 70% ethanol extract (MEE) on the development of colonic aberrant crypt foci (ACF) induced by 1,2-dimethylhydrazine (DMH) were investigated. Six-week-old male F344 rats were divided to 7 experimental groups; 1) DMH alone, 2) DMH+0.3% MWE, 3) DMH+1% MWE, 4) DMH+3% MWE, 5) DMH+1% MEE, 6) 3% MWE alone and 7) normal control. Animals were subcutaneously injected with DMH (30 mg/kg) 4 times to induce colonic ACF during the initial 2 weeks, and fed with a basal containing various concentrations of test materials (MWE or MEE) for 8 weeks including the DMH-treatment period. The formation of ACF on colonic mucosa was observed after staining with methylene blue. There are no specific effects of MWE and MEE on body weight, feed and water consumptions, organ weights, histopathological observations, and hematological and blood chemistry analyses. Challenge with DMH alone induced mean number of 270.1 ACF/colon which was somewhat inhibited by MWE treatment, showing average numbers of 234.3-242.1 ACF/colon. In comparison, the ACF number was significantly suppressed to 216.5 by administration of 1% MEE. Therefore, these results suggest that Magnolia ovobata extracts, especially MEE, exert a chemopreventive effect on the DMH-induced colon cancer by inhibiting the early development of ACF.
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참고문헌
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Abrams,J.M / 2002 / Competition and compensation: coupled to death in development and cancer / Cell 110 (4) : 403 ~ 406
2. [학술지(정기간행물)] - Arias, A.M / 2001 / Epithelial mesenchymal interactions in cancer and development / Cell 105 (4) : 425 ~ 431
3. [학술지(정기간행물)] - Bai, X / 2003 / Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo / J. Biol. Chem 278 (37) : 35501 ~ 35507
4. [학술지(정기간행물)] - Bird,R.P / 1987 / Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings / Cancer Lett 37 (2) : 147 ~ 151
5. [학술지(정기간행물)] - Bird, R.P / 2000 / The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer / Toxicol. Lett 112-113 : 395 ~ 402
2. [학술지(정기간행물)] - Arias, A.M / 2001 / Epithelial mesenchymal interactions in cancer and development / Cell 105 (4) : 425 ~ 431
3. [학술지(정기간행물)] - Bai, X / 2003 / Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo / J. Biol. Chem 278 (37) : 35501 ~ 35507
4. [학술지(정기간행물)] - Bird,R.P / 1987 / Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings / Cancer Lett 37 (2) : 147 ~ 151
5. [학술지(정기간행물)] - Bird, R.P / 2000 / The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer / Toxicol. Lett 112-113 : 395 ~ 402
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백서에서 셀룰로즈 함유식이에 의한 대장 통과시간과 대사성 변화가 1, 2-Dimethylhydrazine 유발대장암에 미치는 영향에 관한 연구
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Protective Roles of Mushrooms in Experimental Colon Carcinogenesis
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UCI(KEPA) : I410-ECN-0101-2009-510-014844062