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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 381 - 385 (5page)
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초록· 키워드
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Indole-3-carbinol (I3C), one of naturally occurring main components in cauliflower vegetables, is supposed to have a chemopreventive potential in experimental animals and humans. This study was investigated to examine chemopreventive effect of I3C on colon carcinogenesis induced by azoxymethane (AOM) using C57BL/6J mice. Mice were divided into three groups (10 or 9 mice/group). All mice were subcutaneously injected with AOM (5 ㎎/㎏ body weight, four times at weekly interval). After AOM treatment, animals of group 1 were fed by AIN-76A pellets as a basal diet. Animals of groups 2 and 3 were given I3C containing diets (100 and 300 ppm in diets, respectively) for 6 weeks until sacrifice. All mice were sacrificed at week 10 and the aberrant crypt foci (ACF) of the colonic mucosa were assessed after staining with methylene blue. Total numbers of ACF/colon in group 2 (10.1±5.1) or group 3 (10.6±5.3) were decreased compared to the values of group 1 (14.4±10.2). Among numbers of ACF formation, 5, 7, 8 and 10 ACF in group 2 and 3 were greatly different those of group 1. Total numbers of aberrant crypts (AC)/colon of group 2 (20.1±10.1) or group 3 (22.0±10.9) were decreased compared to the value of group 1 (33.7±24.7). Taken together, it suggests that I3C treatment may retard mouse colon carcinogenesis even after administration of AOM.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Bird RP / 2000 / The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer / Toxicol Lett 112(113):395~402
Bjeldanes LF / 1991 / Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin / Proc Natl Acad Sci U S A 88:9543~9547
Bonnesen C / 2001 / Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines / Cancer Res 61:6120~6130
Broadbent TA / 1998 / 1 - 1. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3- (methoxymethyl)indole. [Part I] / Curr Med Chem 5:337~352
Cover CM / 1999 / Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells / Cancer Res 59:1244~1251
Bjeldanes LF / 1991 / Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin / Proc Natl Acad Sci U S A 88:9543~9547
Bonnesen C / 2001 / Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines / Cancer Res 61:6120~6130
Broadbent TA / 1998 / 1 - 1. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3- (methoxymethyl)indole. [Part I] / Curr Med Chem 5:337~352
Cover CM / 1999 / Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells / Cancer Res 59:1244~1251
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UCI(KEPA) : I410-ECN-0101-2012-510-004137408