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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 41 - 45 (5page)
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초록· 키워드
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Algal fucoidan is a marine polysaccharide containing sulfur with a wide variety of biological activities including anti-inflammatory and anti-thrombotic effects. Although antioxidants can inhibit inflammatory signals through inhibiting activator protein-1 and/or nuclear factor-kappaB activation, it is obscure whether fucoidan directly scavenges oxy-radicals or indirectly regulates oxidant production and/or antioxidant defense system The antioxidant activities of fucoidan against peroxyl radicals, peroxynitrites and hydroxyl radicals were determined by the total oxy-radical scavenging capacity (TOSC) assay. The specific TOSC values of fucoidan against peroxyl radicals, peroxynitrites or hydroxyl radicals were 282±60, 43±1 or 40±1 TOSC/mg/mL, respectively. These specific TOSC values against peroxyl radicals, peroxynitrites or hydroxyl radicals are 23, 12, or 13% of the specific TOSC values of glutathione, a positive control, respectively. These results suggest that fucoidan has direct oxy-radical scavenging capacity, which may be related with anti-inflammatory effect of fucoidan.
목차
ABSTRACT
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재료 및 방법
결과 및 고찰
감사의 글
참고문헌
참고문헌 (9)
참고문헌 신청
1. [학술지(정기간행물)] - Berteau O / 2003 / Sulfated fucans, fresh perspectives:structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide / Glycobiology 13 (6) : 29R ~ 40R
2. [학술지(정기간행물)] - Biesalski HK / 2007 / Polyphenols and inflammation: basic interactions / Curr Opin Clin Nutr Metab. Care 10 (6) : 724 ~ 728
3. [학술지(정기간행물)] - Brown GC / 2007 / Mechanisms of inflammatory neurodegeneration:iNOS and NADPH oxidase / Biochem Soc Trans 35 (Pt 5) : 1119 ~ 1121
4. [학술지(정기간행물)] - Lu Y / 2008 / CYP2E1 and oxidative liver injury by alcohol / Free Radic Biol Med 44 (5) : 723 ~ 738
5. [학술지(정기간행물)] - Pannu R / 2006 / Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms / Neurochem Int 49 (2) : 170 ~ 182
2. [학술지(정기간행물)] - Biesalski HK / 2007 / Polyphenols and inflammation: basic interactions / Curr Opin Clin Nutr Metab. Care 10 (6) : 724 ~ 728
3. [학술지(정기간행물)] - Brown GC / 2007 / Mechanisms of inflammatory neurodegeneration:iNOS and NADPH oxidase / Biochem Soc Trans 35 (Pt 5) : 1119 ~ 1121
4. [학술지(정기간행물)] - Lu Y / 2008 / CYP2E1 and oxidative liver injury by alcohol / Free Radic Biol Med 44 (5) : 723 ~ 738
5. [학술지(정기간행물)] - Pannu R / 2006 / Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms / Neurochem Int 49 (2) : 170 ~ 182
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UCI(KEPA) : I410-ECN-0101-2009-539-014643833