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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 235 - 240 (6page)
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초록· 키워드
오류제보하기
Primary skin irritation and skin sensitization induced by Rosin<SUP>®</SUP>, an extract of pine tree, were assessed in rabbits and guinea pigs, respectively, according to the guidelines of Korea Food and Drug Administration. In primary skin irritation test, 5% and 10% of Rosin<SUP>®</SUP> (in 80% ethanol) exhibited mean score 1.17 and 1.33, respectively, leading to primary irritation indices (PII) of 0.29 and 0.33. Thus, the test compound Rosin<SUP>®</SUP> was evaluated to be a ‘non-irritant’ material. In skin sensitization study using guinea pig maximization test (GPMT), 5% and 10% Rosin<SUP>®</SUP> did not induce erythema or edema, displaying sensitization score 0 and rate 0%, whereas 0.1% 2,4-dinitrochrolobenzene (DNCB), a positive control, induced sensitization scores 1-2 and rate 80%. Therefore, Rosin<SUP>®</SUP> and DNCB were classified to grade Ⅰ and Ⅳ, indicating weak and strong sensitizers, respectively. Taken together, it is suggested that Rosin<SUP>®</SUP> is a pratically-safe material to skin without potential of irritation or allergic sensitization.
목차
재료 및 방법
결과 및 고찰
감사의 글
참고문헌
참고문헌 (16)
참고문헌 신청
Andersen, K.E , 1995 , The guinea pig maximization test-with a multiple dose design , Acta Dermatol. Venereol 75 (6) : 463 ~ 469
Bocca, B , 2007a , Levels of nickel and other potentially allergenic metals in Ni-tested commercial body creams , J. Pharmaceut. Biomed. Anal 44 : 1197 ~ 1202
Bocca, B , 2007b , A pilot study on the content and the release of Ni and other allergenic metals from cheap earrings available on the Italian market , Sci. Total Environ 388 : 24 ~ 34
Kimber, I , 2001 , Skin sensitization testing in potency and risk assessment , Toxicol Sci 59 (2) : 198 ~ 208
Choi, C-S , 2005 , The Observation of the Skin Contact Allergic Sensitization Test of Rhus-II with Guinea Pig Maximization Test , J. Fd Hyg. Safety 20 (1) : 13 ~ 17
Bocca, B , 2007a , Levels of nickel and other potentially allergenic metals in Ni-tested commercial body creams , J. Pharmaceut. Biomed. Anal 44 : 1197 ~ 1202
Bocca, B , 2007b , A pilot study on the content and the release of Ni and other allergenic metals from cheap earrings available on the Italian market , Sci. Total Environ 388 : 24 ~ 34
Kimber, I , 2001 , Skin sensitization testing in potency and risk assessment , Toxicol Sci 59 (2) : 198 ~ 208
Choi, C-S , 2005 , The Observation of the Skin Contact Allergic Sensitization Test of Rhus-II with Guinea Pig Maximization Test , J. Fd Hyg. Safety 20 (1) : 13 ~ 17
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