지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.13 No.4
- 발행연도
- 2008.12
- 수록면
- 253 - 258 (6page)
이용수
초록· 키워드
오류제보하기
The anti-inflammatory activities of an ethanol extract of Caesalpinia sappan L. (CS) were investigated in LPS-induced RAW 264.7 cells. Result indicated that CS inhibited the LPS-induced NO production in a dose-dependent manner with an IC?? of 10.9 ㎍/mL. In addition, CS attenuated the iNOS mRNA and protein expression by inhibiting NF-κB activation. CS also suppressed the productions of IL-6 and MCP-1 in a dose-dependent manner, with IC?? values of 15.9 ㎍/mL and 5.47 ㎍/mL, respectively. In addition to the anti-inflammatory activities, CS decreased intracellular ROS formation in the same cells. In conclusion, CS inhibited the production of NO, IL-6 and MCP-1 via a suppression of the NF-κB activation and intracellular ROS generation.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSIONS
ACKNOWLEDGMENTS
REFERENCES
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Safitri R / 2003 / Antioxidant activity in vitro of two aromatic compounds from Caesalpinia sappan L / Biofactors 19 : 71 ~ 77
2. [학술지(정기간행물)] - Kim EC / 2005 / Caesalpinia sappan induces cell death by increasing the expression of p53 and p21WAF1/CIP1 in head and neck cancer cells / Am J Chinese Med 33 : 405 ~ 414
3. [학술지(정기간행물)] - Baek NI / 2000 / Anticonvulsant compounds from the wood of Caesalpinia sappan L / Arch Pharm Res 23 : 344 ~ 348
4. [학술지(정기간행물)] - Oh SR / 1998 / Anticomplementary activity of constituents from the heartwood of Caesalpinia sappan.Planta Med 64:456-458 / Planta Med 64 : 456 ~ 458
5. [학술지(정기간행물)] - Bae IK / 2005 / Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells / Eur J Pharmacol 513 : 237 ~ 242
2. [학술지(정기간행물)] - Kim EC / 2005 / Caesalpinia sappan induces cell death by increasing the expression of p53 and p21WAF1/CIP1 in head and neck cancer cells / Am J Chinese Med 33 : 405 ~ 414
3. [학술지(정기간행물)] - Baek NI / 2000 / Anticonvulsant compounds from the wood of Caesalpinia sappan L / Arch Pharm Res 23 : 344 ~ 348
4. [학술지(정기간행물)] - Oh SR / 1998 / Anticomplementary activity of constituents from the heartwood of Caesalpinia sappan.Planta Med 64:456-458 / Planta Med 64 : 456 ~ 458
5. [학술지(정기간행물)] - Bae IK / 2005 / Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells / Eur J Pharmacol 513 : 237 ~ 242
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