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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 527 - 542 (16page)
이용수
초록· 키워드
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Safflower seeds which contains large amounts of conjugated linoleic acid and glyceride, are known to have effect on osteoporosis, bone fracture, and cholesterol metabolism. In this study, the 13-week repeated oral dose toxicity study of Safflower seeds was performed using F344 rats. In 14-day repeated dose study to determine the adequate dosage of safflower seeds administration, no other important changes were observed except statistically significant decreases in the mean absolute weights of the liver and the mean liver weight relative to body weight. It was dose-related finding at groups higher than 0.015 g/㎏ body weight (B.W.) in males and 0.045 g/㎏ B.W. in females. Based on preliminary test, safflower seeds was orally administered five times per week, weekday only to 5 groups of 6-week-old 10 male and 10 female F344 rats at dosage levels of 0.003, 0.016, 0.08, 0.4 and 2 g/㎏/day. The control group, also consisting of 10 males and 10 females, received the vehicle, 1% methylcellulose (MC), on a comparable regimen. One male and a female in the 0.4 g/㎏/day group, and a female in the 2 g/㎏/day group were found dead but the death could not be related to test article toxicity. No test article-related effect was observed on clinical signs and water consumption. For the 2 g/㎏/day males, there were significant decrease in body weight changes and food consumption from 10th week to study termination. The statistically significant decreases in the mean absolute weights of liver and the mean liver weight relative to body weight of the 0.003, 0.016 and 2 g/㎏/day group males and 0.003, 0.016 and 0.08 g/㎏/day females showed no dose related pattern and considered not to be test article related. There were no dose-related changes in hematology, biochemistry parameters, sperm morphology and vaginal cytology of all animals treated with safflower seeds. Gross and histopathological findings revealed no evidence of specific toxicity related to safflower seeds. These results suggest that no-observed adverse-effect level (NOAEL) of the test substance was considered to be 2 g/㎏/day for male and female rats under the conditions in this study.
목차
재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (14)
참고문헌 신청
1. [단행본] - Hayes, A.W. / 2008 / Principles and Methods of Toxicology, 5th ed / CRC Press : 591 ~ 1264
2. [학술지(정기간행물)] - 최윤화 / 2004 / 시험관내에서 홍화의 물 추출물이 T 및 B 림프구의 활성에 미치는 영향 / 생약학회지 35 (4) : 330 ~ 337
3. [학술지(정기간행물)] - Hur, S.J. / 2007 / Biological activities of conjugated linoleic acid (CLA) and effects of CLA on animal products / Livestock Sci 110 : 221 ~ 229
4. [학술지(정기간행물)] - Jeon, S.M. / 1998 / The effects of Korean safflower (Carthamus tinctorious L.) seed powder supplementation diet on bone metabolism indices in rats during the recovery of rib fracture / Korean J. Nutr 31 (6) : 1049 ~ 1056
5. [학술지(정기간행물)] - Jung, C.G. / 1989 / Study on the effects of Astragali radix, Cinnamomi ramulus and Carthami flos on thrombosis and elevated blood viscosity / J. Korean Oriental Med. Pathol 4 : 74 ~ 92
2. [학술지(정기간행물)] - 최윤화 / 2004 / 시험관내에서 홍화의 물 추출물이 T 및 B 림프구의 활성에 미치는 영향 / 생약학회지 35 (4) : 330 ~ 337
3. [학술지(정기간행물)] - Hur, S.J. / 2007 / Biological activities of conjugated linoleic acid (CLA) and effects of CLA on animal products / Livestock Sci 110 : 221 ~ 229
4. [학술지(정기간행물)] - Jeon, S.M. / 1998 / The effects of Korean safflower (Carthamus tinctorious L.) seed powder supplementation diet on bone metabolism indices in rats during the recovery of rib fracture / Korean J. Nutr 31 (6) : 1049 ~ 1056
5. [학술지(정기간행물)] - Jung, C.G. / 1989 / Study on the effects of Astragali radix, Cinnamomi ramulus and Carthami flos on thrombosis and elevated blood viscosity / J. Korean Oriental Med. Pathol 4 : 74 ~ 92
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