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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 377 - 383 (7page)
이용수
초록· 키워드
오류제보하기
Menopause is a natural phenomenon as women age and estrogen levels decline. Estrogen deficiency is the primary cause of menopause. Hormone replacement therapy with estrogen is a popular preventive therapy for prevention and treatment of menopause syndrome. Consequently, EstroG-200 was developed for a hormone replacement therapy. EstroG-200 is a mixture-extract of 3 herbs composed of dried radix of Angelica gigas, Cynanchum wilfordii and Phlomis umbrosa. This study was performed to evaluate the potential subchronic toxicity of EstroG-200 in Sprague-Dawley rats. EstroG-200 was administered once daily by oral gavage to male and female rats at dose levels of 0, 250, 500, and 1,000 ㎎/㎏/day. All rats were sacrificed after 13 weeks of dosing. No adverse treatment related effects were evident in any parameters evaluated; clinical signs, mortality, body weights, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, necropsy findings, organ weights, and histopathological evaluations at any dose level. There were no indications of any adverse effects in any tissues, organs or organ systems. The no-observed-effect level (NOEL) was considered to be ≥1,000 ㎎/㎏/day for both sexes under the conditions of this study.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Baker, V.L. / 2000 / Selective estrogen receptor modulators in reproductive medicine and biology / Obstet. Gynecol. Surv 55 (7) : S21 ~ S47
2. [학술지(정기간행물)] - Choi, S.S. / 2003 / Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models / Biol. Pharm. Bull 26 (9) : 1283 ~ 1288
3. [학술지(정기간행물)] - Elfturi, A. / 2005 / Two hormone replacement therapy (HRT) regimens for middleeastern postmenopausal women / Maturitas 52 (1) : 52 ~ 59
4. [학술지(정기간행물)] - Fandti, P. / 1998 / The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats / Osteroporos Int 8 (3) : 274 ~ 281
5. [학술지(정기간행물)] - 강순아 / 2003 / 한국 · 중국 · 일본 당귀가 cyclophosphamide로 유발된 흰쥐의 빈혈에 미치는 영향의 차이 / 한국식품과학회지 35 (6) : 1204 ~ 1208
2. [학술지(정기간행물)] - Choi, S.S. / 2003 / Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models / Biol. Pharm. Bull 26 (9) : 1283 ~ 1288
3. [학술지(정기간행물)] - Elfturi, A. / 2005 / Two hormone replacement therapy (HRT) regimens for middleeastern postmenopausal women / Maturitas 52 (1) : 52 ~ 59
4. [학술지(정기간행물)] - Fandti, P. / 1998 / The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats / Osteroporos Int 8 (3) : 274 ~ 281
5. [학술지(정기간행물)] - 강순아 / 2003 / 한국 · 중국 · 일본 당귀가 cyclophosphamide로 유발된 흰쥐의 빈혈에 미치는 영향의 차이 / 한국식품과학회지 35 (6) : 1204 ~ 1208
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UCI(KEPA) : I410-ECN-0101-2010-510-001694199