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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 601 - 607 (7page)
이용수
이 논문의 연구 히스토리 (5)
2008
Effect of Phytic Acid on the Formation of Colonic Aberrant Crypt Foci induced by azoxymethane in Fe-deficient ICR Mice
Jin-Joo Hue
,
Ji-Yeon Han
,
Ki-Nam Lee
외 7명
Laboratory Animal Research
2008.12
학술저널
Protective effect of phytic acid on the formation of aberrant crypt foci induced by azoxymethane in the colon of male ICR mice
Jin-Joo Hue
,
Ki-Nam Lee
,
Myak Miga
외 5명
한국실험동물학회 학술발표대회 논문집
2008.11
학술대회자료
Protective effect of phytic acid on the formation of aberrant crypt foci induced by azoxymethane in the colon of male ICR mice
Jin-Joo Hue
,
Ki-Nam Lee
,
Bong Su Kang
외 4명
Journal of Biomedical Research
2008.06
학술저널
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초록· 키워드
오류제보하기
Phytic acid (PA) has chelating and reducing properties on many divalent transition metals. Its properties may be associated with a role in anticancer activity. In the present study, effects of PA on colon carcinogenesis were investigated in Fe-deficient ICR male mice. Five-week old mice were acclimated for one week and assigned to five experimental groups including normal control, azoxymethane (AOM) only, AOM+low Fe, AOM+low Fe+0.5% PA, and AOM+low Fe+2% PA groups. Animals fed on iron-normal diet (35 ppm Fe) or iron-deficient diet (3 ppm Fe) and PA (0.5% or 2% PA in water) for 8 weeks. Animals received three (0-2nd weeks after starting experiment) injections of AOM (10 ㎎/㎏ bw) to induce colonic aberrant crypt foci (ACF). The total numbers of ACF and aberrant crypt (AC) were measured in the colonic mucosa stained with methylene blue. The blood and serum were analyzed with a blood cell differential counter and an automatic serum analyzer. Low iron diet induced a significant low in hemoglobin and mean corpuscular volume and hemoglobin values, compared with normal diet group (P＜0.05). AOM treatment induced total numbers of 81.7 ACF and 102.0 AC per colon in normal iron-diet (AOM alone) group. Low dietary iron (AOM LFe) decreased the numbers of ACF (64.9) and AC (79.8) per colon by 20.6 and 21.8%, respectively, compared with AOM alone group. Treatment of 0.5% PA significantly decreased the numbers of ACF (50.3) and AC (60.5) per colon by 22.5 and 24.2%, respectively, compared with AOM LFe group (P＜0.05). PA at 2% also reduced the formation of ACF or AC by 13.3 and 18.3%, respectively, compared with AOM LFe group (P＜0.05). No detrimental effects by PA treatment were observed in blood and serum chemistry, body weight, and relative organ weight of mice during the experimental period. These findings suggest that PA may prevent colon carcinogenesis in mice even with iron-deficient status.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (38)
참고문헌 신청
1. [학술지(정기간행물)] - Babbs, C.F / 1990 / Free radicals and the etiology of colon cancer / Free Radic. Biol. Med 8 : 191 ~ 200
2. [학술지(정기간행물)] - Baten, A. / 1989 / Inositol-phosphate-induced enhancement of natural killer cell activity correlates with tumor suppression / Carcinogenesis 10 : 1595 ~ 1598
3. [학술지(정기간행물)] - Bird, R.P / 1987 / Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings / Cancer Lett 137 : 147 ~ 151
4. [학술지(정기간행물)] - Bruce, W.R. / 2000 / Possible Mechanisms relating diet and risk of colon cancer / Cancer Epidemiol. Biomarkers Prev 9 : 1271 ~ 1279
5. [학술지(정기간행물)] - Davis, C.D. / 1999 / Dietary copper, manganese and iron affect the formation of aberrant crypts in colon of rats administered 3,2'-dimethyl-4-aminobiphenyl / J. Nutr 129 : 1060 ~ 1067
2. [학술지(정기간행물)] - Baten, A. / 1989 / Inositol-phosphate-induced enhancement of natural killer cell activity correlates with tumor suppression / Carcinogenesis 10 : 1595 ~ 1598
3. [학술지(정기간행물)] - Bird, R.P / 1987 / Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings / Cancer Lett 137 : 147 ~ 151
4. [학술지(정기간행물)] - Bruce, W.R. / 2000 / Possible Mechanisms relating diet and risk of colon cancer / Cancer Epidemiol. Biomarkers Prev 9 : 1271 ~ 1279
5. [학술지(정기간행물)] - Davis, C.D. / 1999 / Dietary copper, manganese and iron affect the formation of aberrant crypts in colon of rats administered 3,2'-dimethyl-4-aminobiphenyl / J. Nutr 129 : 1060 ~ 1067
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UCI(KEPA) : I410-ECN-0101-2009-510-015707106