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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.9
- 수록면
- 293 - 300 (8page)
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초록· 키워드
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The role of selenium (Se) in modulating colon carcinogenesis induced by azoxymethane (AOM) followed by dextran sodium sulfate (DSS) was investigated in mice. Five-week old ICR mice were fed on diets containing different concentrations (0.02, 0.1 or 0.5 ppm) of Se for 24 weeks. Animals received three (0-2nd weeks) intraperitoneal injections of AOM (10 ㎎/㎏ body weight), followed by 2% DSS with drinking water for additional 1 week. There were 4 experimental groups including vehicle control group, positive control group given AOM/DSS with AIN-93G normal diet containing 0.1% Se (NSe), a low (0.02 ppm)-Se diet group (LSe) and a high (0.5 ppm)-Se diet group (HSe). Hematology was analyzed with a blood cell differential counter. Liver Se was analyzed by inductively coupled plasma-mass spectroscopy. Cell proliferation and apoptosis were determined by using proliferating cell nuclear antigen (PCNA) for proliferative activity and apoptotic index by terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling (TUNEL), respectively. HSe group showed a low incidence of colonic tumor (64.7%), compared with the NSe positive control (75%) and LSe (77.8%) groups. In contrast, HSe group exhibited lower rate of PCNA-positive cells (39.3±6.9%) than positive control (64.3±0.3%) and LSe (57.3±2.9%) groups. In addition, apoptotic index of HSe group was higher than those of positive control and LSe groups. These results indicate that Se is a chemopreventive agent for colon carcinogenesis induced by AOM+DSS in male ICR mice.
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감사의 글
참고문헌
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - Abdulah, R. / 2005 / Chemical forms of selenium for cancer prevention / J. Trace Elem. Med. Biol. 19 (2-3) : 141 ~ 150
2. [학술지(정기간행물)] - Beno, I. / 2000 / Blood levels of natural antioxidants in gastric and colorectal precancerous lesions and cancers in Slovakia / Neoplasma 47 (1) : 37 ~ 40
3. [학술지(정기간행물)] - Bravo, R. / 1987 / Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta / Nature 326 (6112) : 515 ~ 517
4. [학술지(정기간행물)] - Choi, Y.S. / 2006 / Nutritional Biochemistry of selenium / J. Kor. Soc. Food Sci. Nutr. 35 (5) : 661 ~ 670
5. [학술지(정기간행물)] - Clark, L.C. / 1996 / Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group / JAMA 276 (24) : 1957 ~ 1963
2. [학술지(정기간행물)] - Beno, I. / 2000 / Blood levels of natural antioxidants in gastric and colorectal precancerous lesions and cancers in Slovakia / Neoplasma 47 (1) : 37 ~ 40
3. [학술지(정기간행물)] - Bravo, R. / 1987 / Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta / Nature 326 (6112) : 515 ~ 517
4. [학술지(정기간행물)] - Choi, Y.S. / 2006 / Nutritional Biochemistry of selenium / J. Kor. Soc. Food Sci. Nutr. 35 (5) : 661 ~ 670
5. [학술지(정기간행물)] - Clark, L.C. / 1996 / Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group / JAMA 276 (24) : 1957 ~ 1963
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Modifying Effect of Indole-3-carbinol on the Rat Colon Carcinogenesis
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Pomegranate (Punica granatum) Peel Extract Efficacy as a Dietary Antioxidant against Azoxymethane-Induced Colon Cancer in Rat
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UCI(KEPA) : I410-ECN-0101-2012-510-003686493