지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.14 No.3
- 발행연도
- 2009.9
- 수록면
- 179 - 187 (9page)
이용수
초록· 키워드
오류제보하기
Five kinds of coumarin compounds were successfully purified from Angelica gigas Nakai by using recyclingpreparative HPLC and identified as decursin (1), decursinol angelate (2), 7-demethylsuberosine (3), marmesin (4), and decursinol (5) by NMR analyses. None of the purified compounds in ethanol showed DPPH radical scavenging activity, while the A. gigas extract (AGNEX) displayed a significant level of activity. Interestingly, compounds 3 in phosphate buffered saline (PBS) showed good ABTS<SUP>+</SUP> radical scavenging activity (IC<SUB>50</SUB>=8.1 ㎍/mL) as did compounds 4 and 5. The anti-inflammatory activities of the purified compounds were evaluated and compared using the NO concentration assay and western blot analysis on LPS-stimulated RAW 264.7 cells. NO production was significantly suppressed by all the compounds in a dose-dependent manner among which compounds 1, 2, and 3 showed very good activities with IC<SUB>50</SUB> values of 7.4, 6.5, and 7.6 ㎍/mL, respectively. Treatment with compounds 1-5 effectively suppressed the expression levels of iNOS, IL-1β, and COX-2, which are responsible for promoting the inflammatory process. Thus, the ethanol extract and coumarin compounds of A. gigas Nakai hold promise for use as potential anti-inflammatory agents.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Sarker SD / 2004 / Natural medicine: the genus Angelica / Curr Med Chem : 1479 ~ 1500
2. [학술지(정기간행물)] - Lee S / 2003 / Anti-bacterial coumarins from Angelica gigas roots / Arch Pharm Res : 449 ~ 452
3. [학술지(정기간행물)] - Jiang C / 2007 / Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells / Breast Cancer Res : R77 ~
4. [학술지(정기간행물)] - Jiang C / 2006 / Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer / Cancer Res : 453 ~ 463
5. [학술지(정기간행물)] - Song GY / 2007 / Decursin suppresses human androgen-independent PC3 prostate cancer cell proliferation by promoting the degradation of β-catenin / Mol Pharmacol : 1599 ~ 1606
2. [학술지(정기간행물)] - Lee S / 2003 / Anti-bacterial coumarins from Angelica gigas roots / Arch Pharm Res : 449 ~ 452
3. [학술지(정기간행물)] - Jiang C / 2007 / Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells / Breast Cancer Res : R77 ~
4. [학술지(정기간행물)] - Jiang C / 2006 / Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer / Cancer Res : 453 ~ 463
5. [학술지(정기간행물)] - Song GY / 2007 / Decursin suppresses human androgen-independent PC3 prostate cancer cell proliferation by promoting the degradation of β-catenin / Mol Pharmacol : 1599 ~ 1606
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UCI(KEPA) : I410-ECN-0101-2009-511-018845708