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Intestine Ischemia/reperfusion Induces ER Stress and Apoptosis in Miniature Pigs
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Type
Academic journal
Author
Jae-Cheong Lim (전남대학교) Ho-Jae Han (전남대학교) Soo-Hyun Park (전남대학교)
Journal
The Korean Society For Biomedical Laboratory Sciences Biomedical Science Letters Vol.16 No.4 KCI Accredited Journals
Published
2010.12
Pages
359 - 363 (5page)

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Intestine Ischemia/reperfusion Induces ER Stress and Apoptosis in Miniature Pigs
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The miniature pig is a very suitable donor species in xenotransplantation of human organs. Intestine ischemia/ reperfusion (I/R) is associated with high morbidity and mortality. Endoplasmic reticulum (ER) stress and apoptosis has been associated with the onset of diverse diseases. Thus, we examined the effect of intestine I/R on the expression of ER stress and apotptosis related molecules. In the present study, I/R induced phosphorylation of protein kinase-like endoplasmic reticulum kinase (PERK), IRE, and ATF-4. I/R also increased the expression of the proapoptotic transcription factor CAAT/enhancer-binding protein homologous protein (CHOP). In addition, I/R decreased the expression of Bcl-2, but increased the expression of Bax, cleaved PARP, and cleaved caspase-3. Moreover, I/R increased splicing form of XBP-1 mRNA and the expression of caspase-6 and caspase-3 mRNA. In conclusion, intestine I/R induced ER stress and apoptosis in miniature pig.
#Xenotransplantion #Intestine #Ischemia/reperfusion #ER stress #Apoptosis

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REFERENCES

References (23)

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Alnemri ES / 1997 / Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases / J Cell Biochem 64:33~42 google schola Boyle EM Jr / 1996 / Endothelial cell injury in cardiovascular surgery: ischemia-reperfusion / Ann Thorac Surg 62:1868~1875 google schola Chen X / 2002 / The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi / J Biol Chem 277:13045~13052 google schola Ji Hyun Choi / 2010 / Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction / Experimental and Molecular Medicine 42(12):811~822 google schola Crissinger RL / 1989 / Mucosal injury induced by ischemia and reperfusion in the piglet intestine: influence of age and feeding / Gastroenterology 97:920~926 google schola

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