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논문 기본 정보

자료유형
학술저널
저자정보
Eunjin Park (Cheju National University) Nam Ho Lee (Cheju National University) Gin-nae Ahn (Cheju National University) Jong Seok Baik (Cheju National University) Jehee Lee (Cheju National University) Kyu-Kye Hwang (Cheju National University) Jae Woo Park (Cheju National University) Youngheun Jee (Cheju National University)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 17. no 4
발행연도
2008.8
수록면
718 - 722 (5page)

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초록· 키워드

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Elaeocarpus sylvestris var. ellipticus (E.S.), which contains 1, 2, 3, 4, 6-penta-O-galloyl-beta-D-glucose (PGG), is reported to have the ability to scavenge oxygen radicals, thereby protecting rat neuronal cells from oxidative damage. The potential of an E.S. extract, which contains a rich PGG, to protect radiosensitive lymphocytes and intestinal crypt cells from radiation injury induced by a single whole-body irradiation (WBI) in vivo was investigated. Our results demonstrated that in immune cells, E.S. treatment decreased the percent of tail DNA, a parameter of DNA damage, compared with levels in untreated, irradiated controls. Furthermore, apoptosis was significantly decreased in lymphocytes and intestinal crypt cells of E.S.-treated mice compared with irradiated controls. These results suggest that the E.S. extract can strengthen the radioresistance of radiosensitive lymphocytes and crypt cells by preventing apoptosis. Therefore, it was concluded that E.S. extract has the radioprotective effects in vivo through an inhibition of apoptosis.

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Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References

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