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논문 기본 정보

자료유형
학술저널
저자정보
Saet Byoul Lee (Korea Institute of Science and Technology Gangneung Institute) Joo Young Lee (Korea Institute of Science and Technology Gangneung Institute) Dae-Geun Song (Korea Institute of Science and Technology Gangneung Institute) Cheol-Ho Pan (Korea Institute of Science and Technology Gangneung Institute) Chu Won Nho (Korea Institute of Science and Technology Gangneung Institute) Min Cheol Kim (Korea Institute of Science and Technology Gangneung Institute) Eun Ha Lee (Korea Institute of Science and Technology Gangneung Institute) Sang Hoon Jung (Korea Institute of Science and Technology Gangneung Institute) Hyung-Seop Kim (Kangnung National University) Yeong Shik Kim (Seoul National University) Byung Hun Um (Korea Institute of Science and Technology Gangneung Institute)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 17. no 3
발행연도
2008.6
수록면
613 - 622 (10page)

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Cancer chemopreventive effects can be exerted through the induction of phase II detoxification enzymes and the inhibition of inflammatory responses. In this study, the cancer chemopreventive effects and anti-inflammatory responses of 30 seaweed extracts were examined. The extracts of Dictyota coriacea and Cutleria cylindrica exhibited the high chemoprevention index, having 4.36 and 4.66, respectively. They also activated antioxidant response element at 100 μg/mL by about 3-fold while did not activate xenobiotic response element. Seven seaweed extracts, Ishige okamurae, Desmarestia ligulata, Desmarestia viridis, Dictyopteris divaricata, D. coriacea, Sargassum horneri, and Sargassum yezoense, showed significant inhibition on nitric oxide (NO) and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) production in a dose-dependant manner in 5-20 μg/mL. These seaweed extracts could be used as food materials for cancer chemoprevention. D. coriacea could contain potential chemopreventive agents not only that regulate genes via an ARE-dependent mechanism but also prevent the inflammation through inhibition of NO and PGE<sub>2</sub> production.

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Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References

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