지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.3
- 수록면
- 159 - 167 (9page)
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Purpose: APC (adenomatous polyposis coli) gene is one of the tumor-suppressor genes that acts in the early stages of cancer. Among general colon cancer patients, normal APC gene expression is deficient in 80%. It seems that APC is the most important gene in the development of colon cancer. This study was performed to analyze the mutation spectra of APC gene in sporadic colon cancer tissue from Korean patients with colon cancer.
Methods: A total of 38 patients with sporadic colon cancer were enrolled. Colon cancer tissues were analyzed for the determination of APC gene mutation spectra by multiplex ligation-dependent probe amplification (MLPA) method using SALSA MLPA P403 APC kit (MRC-Holland, Amsterdam, NL).
Results: APC gene mutations showing deletion/duplication in one or more exons were detected in 23 (60.5%) patients. Duplication in 13 patients (56.5%), duplication and deletion in 7 patients (30.4%), and deletion in 3 patients (13.1%) was detected. The incidence of APC gene mutation found in this study was highest in exon 3. From this study, no significant differences were observed with respect to clinicopathologic findings and the presence or absence of APC mutations.
Conclusion: The frequency of APC gene mutation was about 61% in Korean patients with colon cancer, it showed concordance with the previous reports on the frequency of APC gene mutation from Caucasian patients with sporadic colon cancer. However, in contrast to these reports, the frequency of duplication disclosed much higher than those of western countries.
Methods: A total of 38 patients with sporadic colon cancer were enrolled. Colon cancer tissues were analyzed for the determination of APC gene mutation spectra by multiplex ligation-dependent probe amplification (MLPA) method using SALSA MLPA P403 APC kit (MRC-Holland, Amsterdam, NL).
Results: APC gene mutations showing deletion/duplication in one or more exons were detected in 23 (60.5%) patients. Duplication in 13 patients (56.5%), duplication and deletion in 7 patients (30.4%), and deletion in 3 patients (13.1%) was detected. The incidence of APC gene mutation found in this study was highest in exon 3. From this study, no significant differences were observed with respect to clinicopathologic findings and the presence or absence of APC mutations.
Conclusion: The frequency of APC gene mutation was about 61% in Korean patients with colon cancer, it showed concordance with the previous reports on the frequency of APC gene mutation from Caucasian patients with sporadic colon cancer. However, in contrast to these reports, the frequency of duplication disclosed much higher than those of western countries.
목차
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방법
결과
고찰
결론
REFERENCES
참고문헌 (25)
참고문헌 신청
1. [보고서] - Ministry of Health and Welfare / 2002 / 2001 Annual Report of the Korea Central Cancer Registry
2. [보고서] - Korea National Statistical Office / 2006 / 2005 Annual Report on the Cause of Death Statistics
3. [학술지(정기간행물)] - Vogelstein B / 1988 / Genetic alterations during colorectal- tumor development / N Engl J Med 319 : 525 ~ 532
4. [단행본] - Vogelstein B / 2002 / Colorectal tumors. in: The Genetic Basis of Human Cancer. 2nd ed / McGraw-Hill : 583 ~ 612
5. [학술지(정기간행물)] - Ichii S / 1993 / Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP) / Oncogene 8 : 2399 ~ 2405
2. [보고서] - Korea National Statistical Office / 2006 / 2005 Annual Report on the Cause of Death Statistics
3. [학술지(정기간행물)] - Vogelstein B / 1988 / Genetic alterations during colorectal- tumor development / N Engl J Med 319 : 525 ~ 532
4. [단행본] - Vogelstein B / 2002 / Colorectal tumors. in: The Genetic Basis of Human Cancer. 2nd ed / McGraw-Hill : 583 ~ 612
5. [학술지(정기간행물)] - Ichii S / 1993 / Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP) / Oncogene 8 : 2399 ~ 2405
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UCI(KEPA) : I410-ECN-0101-2013-514-002687883