지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.7
- 수록면
- 32 - 40 (9page)
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초록· 키워드
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Purpose: The aim of this study is to evaluate the significance of tumor size as a predictor of biological tumor behavior and to get some information to decide on the proper operative modality by assessing the survival rate for HCC patients.
Methods: Between January 1995 and September 2006, 278 patients with hepatocellular carcinoma (HCC) underwent liver surgery at our hospital. Of the 278 cases, 176 cases (63.3%) underwent liver resection and 102 cases (36.4%) underwent liver transplantation (LT). All the patients were divided into 4 groups according to their tumor size; ＜2 ㎝, 2∼5 ㎝, 5∼10 ㎝ and ＞10 ㎝. We analyzed the pathologic outcomes, survival rates and the outcome of each operative modality, as related to the tumor size.
Results: The incidence of vascular invasion increased with the tumor size (＜2 ㎝: 4.6%, 2∼5 ㎝: 23.3%, 5∼10 ㎝: 32.6%, ＞10 ㎝: 50.0%)(P＜0.005). For the less than 2 ㎝ sized tumor group, the Edmonson-Steiner (E-S) grade III or IV was present in 40.7% of the patients, as compared with 78.9% in the group of patients with a tumor larger than 10 ㎝ (P=0.005). The patients with a larger tumor showed a poorer survival rate. Liver transplantation showed the longer disease free survival compared to liver resection, though there was no significant benefit in the survival rate. Patients with a small sized tumor showed a better outcome when they underwent liver transplantation and patients with a large sized tumor did better when they underwent liver resection.
Conclusion: Tumor size can be used as a preoperative predictor of the pathologic outcome when considering that the larger size of tumor the patients had, the more prevalent was vascular invasion, the tumor cell grade was more advanced and the survival rate was poorer. For patients with small sized HCC, liver transplantation can be considered the appropriate treatment modality.
Methods: Between January 1995 and September 2006, 278 patients with hepatocellular carcinoma (HCC) underwent liver surgery at our hospital. Of the 278 cases, 176 cases (63.3%) underwent liver resection and 102 cases (36.4%) underwent liver transplantation (LT). All the patients were divided into 4 groups according to their tumor size; ＜2 ㎝, 2∼5 ㎝, 5∼10 ㎝ and ＞10 ㎝. We analyzed the pathologic outcomes, survival rates and the outcome of each operative modality, as related to the tumor size.
Results: The incidence of vascular invasion increased with the tumor size (＜2 ㎝: 4.6%, 2∼5 ㎝: 23.3%, 5∼10 ㎝: 32.6%, ＞10 ㎝: 50.0%)(P＜0.005). For the less than 2 ㎝ sized tumor group, the Edmonson-Steiner (E-S) grade III or IV was present in 40.7% of the patients, as compared with 78.9% in the group of patients with a tumor larger than 10 ㎝ (P=0.005). The patients with a larger tumor showed a poorer survival rate. Liver transplantation showed the longer disease free survival compared to liver resection, though there was no significant benefit in the survival rate. Patients with a small sized tumor showed a better outcome when they underwent liver transplantation and patients with a large sized tumor did better when they underwent liver resection.
Conclusion: Tumor size can be used as a preoperative predictor of the pathologic outcome when considering that the larger size of tumor the patients had, the more prevalent was vascular invasion, the tumor cell grade was more advanced and the survival rate was poorer. For patients with small sized HCC, liver transplantation can be considered the appropriate treatment modality.
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서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Parkin DM / 2001 / Estimating the world cancer burden Globocan 2000 / Int J Cancer 94 : 153 ~ 156
2. [기타자료] - Korea Central Cancer registry / / Ministry of Health and Welfare. 2005 Annual Report of the Korea Central Cancer registry
3. [학술지(정기간행물)] - Caturelli E / 2002 / Siena DA, et al. Diagnosis of liver nodules observed in chronic liver disease patients during ultrasound screening for early detection of hepatocellular carcinoma / Am J Gastroenterol 97 : 397 ~ 405
4. [학술지(정기간행물)] - Poon RT / 2001 / Improving survival results after resection of hepatocellular carcinoma a prospective study of 377 patients over 10 years / Ann Surg 234 : 63 ~ 70
5. [학술지(정기간행물)] - Yeung YP / 2005 / Natural history of untreated nonsurgical hepatocellular carcinoma / Am J Gastroenterol 100 : 1995 ~ 2004
2. [기타자료] - Korea Central Cancer registry / / Ministry of Health and Welfare. 2005 Annual Report of the Korea Central Cancer registry
3. [학술지(정기간행물)] - Caturelli E / 2002 / Siena DA, et al. Diagnosis of liver nodules observed in chronic liver disease patients during ultrasound screening for early detection of hepatocellular carcinoma / Am J Gastroenterol 97 : 397 ~ 405
4. [학술지(정기간행물)] - Poon RT / 2001 / Improving survival results after resection of hepatocellular carcinoma a prospective study of 377 patients over 10 years / Ann Surg 234 : 63 ~ 70
5. [학술지(정기간행물)] - Yeung YP / 2005 / Natural history of untreated nonsurgical hepatocellular carcinoma / Am J Gastroenterol 100 : 1995 ~ 2004
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UCI(KEPA) : I410-ECN-0101-2013-514-002691127